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Evaluation of the Black Cumin Seed Oil Role (BCSO) on a Decline in eNOS Expression and Plasma NO Leavels: Initial Studies Kompreventive BCSO for Lung Cancer

Hidayati, Titiek and Akrom, Akrom and Indrayanti, Indrayanti and Sagiran, Sagiran (2017) Evaluation of the Black Cumin Seed Oil Role (BCSO) on a Decline in eNOS Expression and Plasma NO Leavels: Initial Studies Kompreventive BCSO for Lung Cancer. International Journal of Bioscience, Biochemistry and Bioinformatics, 7 (3). pp. 162-168. ISSN 2010-3638

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Abstract

BCSO is effective as an anti-aging agent in cultures of endothelial and macrophage exposed 7.12, dimethyl-benzantracene (DMBA). Reactive radicals damage endothelial tissue, cause inflammatory reactions and have a role in carcinogenesis. Excessive eNOS expression linked to chronic inflammation and carcinogenesis of lung cancer. The research objective was to determine the effect of BCSO on the expression of eNOS and NO levels of macrophage SD rats exposed DMBA. A study used 36 rats SD that divided into 6 groups, given BCSO (0,01, 0,05 and 0.1 ml / day), positive, negative and normal control. Variables were serum levels of NO and eNOS expression in endothelial tissue.The results showed that eNOS expression in DMBA group is higher than the normal group (P <0.05). BCSO will decrease eNOS expression and NO levels. ENOS expression and NO levels in group BCSO 0,01 and 0,05 ml / kg body weight / day lower than the DMBA group (p <0.05), and similar to the normal group (P>0.05). Conclusion: a dose BCSO can degrade endothelial eNOS expression and NO levels of macrophage culture supernatant SD rat DMBA induced.

Item Type: Artikel Umum
Subjects: R Medicine > RS Pharmacy and materia medica
Divisi / Prodi: Faculty of Pharmacy (Fakultas Farmasi) > Pharmacy Doc
Depositing User: Akrom
Date Deposited: 14 May 2018 01:51
Last Modified: 14 May 2018 01:51
URI: http://eprints.uad.ac.id/id/eprint/10274

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