Hasil Cek Similarity Total alkaloid content in various fractions of Tabernaemonata sphaerocarpa Bl. (Jembirit) leaves

Salamah, Nina and Ningsih, D S (2018) Hasil Cek Similarity Total alkaloid content in various fractions of Tabernaemonata sphaerocarpa Bl. (Jembirit) leaves. Ikatan Apoteker Indonesia, IOP Conf. Series: Materials Science and Engineering 259 (2017) 012017.

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Abstract

Tabernaemontana sphaerocarpa Bl. (Jembirit) is one of the Apocynaceae family
plants containing alkaloid compound. Traditionally, it is used as an anti-inflammatory
medicine. It is found to have a new bisindole alkaloid compound that shows a potent cytotoxic
activity in human cancer. This study aimed to know the total alkaloid content in some fractions
of ethanolic extract of T. sphaerocarpa Bl. leaf powder was extracted by maceration method in
70% ethanol solvent. Then, the extract was fractionated in a separatory funnel using water,
ethyl acetate, and hexane. The total alkaloid content in each fraction was analyzed with visible
spectrophotometric methods based on the reaction with Bromocresol Green (BCG). The total
alkaloids in water fraction and ethyl acetate fraction were (0.0312±0.0009)% and
(0.0281±0.0014)%, respectively. Meanwhile, the total alkaloid content in hexane was not
detected. The statistical analysis, performed in SPSS, resulted in a significant difference
between the total alkaloids in water fraction and ethyl acetate fraction. The total alkaloid in
water fraction of T. sphaerocarpa Bl. was higher than the one in ethyl acetate fraction.

Item Type:	Other
Keyword:	T. sphaerocarpa Bl., alkaloid, visible spectrophotometry, fractionation
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Ms Nina Salamah
Date Deposited:	29 Jun 2018 02:40
Last Modified:	15 Oct 2019 03:42
URI:	http://eprints.uad.ac.id/id/eprint/10511

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