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Hasil Penilaian Sejawat "Total alkaloid content in various fractions of Tabernaemonata sphaerocarpa Bl. (Jembirit) leaves"

Salamah, Nina and Ningsih, D S (2018) Hasil Penilaian Sejawat "Total alkaloid content in various fractions of Tabernaemonata sphaerocarpa Bl. (Jembirit) leaves". Ikatan Apoteker Indonesia.

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Abstract

Tabernaemontana sphaerocarpa Bl. (Jembirit) is one of the Apocynaceae family plants containing alkaloid compound. Traditionally, it is used as an anti-inflammatory medicine. It is found to have a new bisindole alkaloid compound that shows a potent cytotoxic activity in human cancer. This study aimed to know the total alkaloid content in some fractions of ethanolic extract of T. sphaerocarpa Bl. leaf powder was extracted by maceration method in 70% ethanol solvent. Then, the extract was fractionated in a separatory funnel using water, ethyl acetate, and hexane. The total alkaloid content in each fraction was analyzed with visible spectrophotometric methods based on the reaction with Bromocresol Green (BCG). The total alkaloids in water fraction and ethyl acetate fraction were (0.0312±0.0009)% and (0.0281±0.0014)%, respectively. Meanwhile, the total alkaloid content in hexane was not detected. The statistical analysis, performed in SPSS, resulted in a significant difference between the total alkaloids in water fraction and ethyl acetate fraction. The total alkaloid in water fraction of T. sphaerocarpa Bl. was higher than the one in ethyl acetate fraction.

Item Type: Other
Uncontrolled Keywords: sphaerocarpa Bl., alkaloid, visible spectrophotometry, fractionation
Subjects: R Medicine > RS Pharmacy and materia medica
Divisi / Prodi: Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User: Ms Nina Salamah
Date Deposited: 02 Jul 2018 03:52
Last Modified: 02 Jul 2018 03:52
URI: http://eprints.uad.ac.id/id/eprint/10522

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