Profile of Nitric Oxide (NO) Levels in Yogyakarta Society

Akrom, Akrom and Susilowati, A and Darmawan, Endang (2015) Profile of Nitric Oxide (NO) Levels in Yogyakarta Society. [Artikel Dosen]

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Abstract

Introduction: Nitric Oxide (NO) is one of the important compounds in the body. Nitric oxide is a factor for
blood vessel relaxant. In a reasonable amount of NO compounds also controlling an important physiological role
in the cell signaling processes and inflammation, however in excessive amounts of NO have a characters as
reactive oxidative, genotoxic and destrukstif for human cells, therefore necessary to study the profil of NO levels
in humans.Aim: To determine the mean levels of NO in the Yogyakarta society based on gender, age and body
mass index (BMI).Methodology: This study used a cross-sectional study design. The respondents are 44 people
consisting of 11 male and 33 female who live in Yogyakarta. A total of 44 respondents who had appropriate the
criteria and agree with informed consent then examined the levels of NO plasma using ELISA method. Results
of the study will be presented in the descriptive and statistical analysis on the relationship of the levels of NO
with gender, age and BMI at 95% confidence level.Results and discussion: From this research, the results
showed mean levels of NO is 17.87±7.80 μmol/L. The results of data analysis by the gender showed mean levels
of NO in male respondents is 21.58±8.42 μmol/L and 16.63±7.31 μmol/L in female respondents. The mean
levels of NO in male respondents was higher than female. However, there is no significant correlation between
mean levels of NO in the male respondents and female based on statistical analysis of independent sample T-test
with p= 0.102 (p>0.05). The mean levels of NO respondents with aged <25 years is lower than aged >25 years.
Respondents were aged <25 years had mean levels of NO is 17.18±8.00 μmol/L while aged >25 years is
21.5±5.86 μmol/L. However, based on statistical analysis with independent sample t-test showed p=0.181
(p>0.05), there is no significant correlation between the mean NO levels aged <25 years with >25 years. The test
results analysis with independent sample t-test showed no significant correlation between the levels of NO in the
non-obese and obese respondents with p=0.060 (p>0.05). Based on the results we know the mean NO levels in
non-obese respondents is 16.55±8.09 μmol/L, where the obese respondents have mean NO levels is 21.00±6.27
μmol/L. From the results of these studies showed the mean levels of NO respondents with obesity is higher than
respondents who are non-obese.Conclusions: The mean NO levels of this research in Yogyakarta society is
17.87±7.80 μmol/L. Based on the gender, the mean levels of NO mile is 21.58±8.42 μmol/L and 16.63±7.31
μmol/L for female. Based on the age, the mean levels of NO with aged <25 years is 17.18±8.00 μmol/L and >25
years is 21.5 ±5.86 μmol/L. Based on the BMI, the mean levels of NO with non-obese is 16.55±8.09 μmol/L and
obese is 21.00±6.27 μmol/L.

Item Type:	Artikel Dosen
Subjects:	R Medicine > R Medicine (General)
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User:	Akrom Akrom
Date Deposited:	17 Sep 2018 01:39
Last Modified:	17 Sep 2018 01:39
URI:	http://eprints.uad.ac.id/id/eprint/10535

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