Rohadi, Didi and Bachri, Moch. Saiful and Nurani, Laela Hayu (2013) Hasil Peer Review Teman Sejawat "Anti Convulsant effect of Ethyil Acetate Fraction and Unsolved Ethyl acecate Fraction from Sirsak Leaf (annona muricata, L.) on Pentylentetrazol induce in Mice". Fakultas Farmasi, Universitas Ahmad Dahlan.
Preview |
Text
anti convulsant effect SMCCR.pdf Download (1MB) | Preview |
Abstract
Background. Ethanol extract from sirsak leaf (annona muricata L.) reported have anticonvulsant activities. For studying it deeply ethanol extract must do fractination by using ethyl acetate, thus resulting ethyl acetat fraction and unsolved ethyl acetat fraction.
Objective. This research aimed to know about anticonvulsant activities from each fraction.
Methods. It research conducted by using mices which divided is to 8 groups, each groups
consist 7 mices which pentylentetrazol induced 90 mg/kg bw. Doses ethyl acetate fraction Groups
(FE) are 100, 200, 400 mg/kg bw, and unsolved ethyl acetate fraction groups are 100, 200, 400 mg/kg
bw. Control group just added Na CMC 0.5% and comparation group added by Phenobarbital dose
50 mg/Kg Bw by using peroral technique. Both ethyl acetat and unsolved ethyl acetat fractions were
given quantificacy test of total flavonoid content by Chang method, calculated as quercetin. All data
should be analyzed by Kruskal Wallis test which continued with Man-Whitney by using reliable level
95%.
Outcome measured. The parameters anticonvulsant activities are clonic and tonic onset,
clonic and tonic incidence , clonic frequency, time and incidence of mortality.
Results. All fractions delayed the onset of tonic and reduced tonic and mortality incidence.
The most decrease of mortality incidence in FE400, while longest delayed the onset of tonic in FT400.
The latency of mortality possessed in FE400, FT100, FT200, FT400 with the higest at FT400. Total
flavonoid of FE is 1,31% and FT is 2,6%.
Conclusion. In conclusion, that all fractions are appeared have anticonvulsive activities mean
while not yet equal Phenobarbital in dose material treatment.
Keywords : Annona muricata, Ethyl acetat fraction, unsolved ethyl acetat fraction,
Anticonvulsant, pentylentetrazol
| Item Type: | Other |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi) |
| Depositing User: | Laela |
| Date Deposited: | 29 Aug 2018 02:40 |
| Last Modified: | 09 Nov 2018 07:39 |
| URI: | http://eprints.uad.ac.id/id/eprint/11137 |
Actions (login required)
 |
View Item |