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Similarity " THE DISSOLUTION AND DIFFUSION OF FUROSEMIDE ON SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS)"

Wahyuningsih, Iis and Sugiyanto, Sugiyanto and Yuswanto, Ag and Martien, Ronny Similarity " THE DISSOLUTION AND DIFFUSION OF FUROSEMIDE ON SELF-NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS)". Farmasi, Universitas Gadjah Mada, Indonesian Juornal Pharmacy, Vol 28 No 2, 2017.

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Abstract

Furosemide a diuretic exhibits low solubility in water and low bioavailability. The purpose of this study was to determine the effect SNEDDS formation to dissolution and diffusion of furosemide. SNEDDS was made with a mixture of 66% tween 80, 26% propylene glycol, 8% oleic acid and furosemide 40mg/mL. Test for SNEDDS dissolution of the capsules was developed using USP dissolution apparatus I and compared to market products, furosemide suspenssion and furosemide powder. The medium consists of 900mL of Artificial Gastric Fluid (AGF) , phosphate buffer pH 5.8 at 37±0.5°C and stirred with a speed of 100rpm. Diffusion test of SNEDDS furosemide was conducted by using reversed rat intestinal bowel and compared to furosemide suspension and furosemide solution. The SNEDDS formulation could enhance the dissolution and diffusion of furosemide compared to the non-SNEDDS formulation Keywords furosemide, SNEDDS, dissolution, diffusion

Item Type: Other
Subjects: R Medicine > RS Pharmacy and materia medica
Divisi / Prodi: Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User: Iis Wahyuningsih
Date Deposited: 30 Nov 2018 03:54
Last Modified: 30 Nov 2018 03:54
URI: http://eprints.uad.ac.id/id/eprint/11759

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