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FORMULATION CHEWABLE TABLET EXTRACT ETANOL ALOE LEAVES ( Aloe Vera L )WITH COMBINATION OF FILLER AVICEL PH 102-MALTODEXTRIN

Dito, Galih and Arif, Budi Setianto and Azis, Ikhsanudin (2012) FORMULATION CHEWABLE TABLET EXTRACT ETANOL ALOE LEAVES ( Aloe Vera L )WITH COMBINATION OF FILLER AVICEL PH 102-MALTODEXTRIN. FORMULATION CHEWABLE TABLET EXTRACT ETANOL ALOE LEAVES ( Aloe Vera L ) WITH COMBINATION OF FILLER AVICEL PH 102-MALTODEXTRIN.

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Abstract

ABSTRACT Aloe leaves (Aloe vera L) is one of plant that can use as laxantive agent, so need to be made practical dosage form as tablet. Tablet manufacture from extract requires combination of filler to obtain up to standard tablet seen from the physical characteristic. This research aim to toward of combination of filler Avicel PH 102 and Maltodextrin to physical characteristic of tablet Aloe leaves extract was getted with maseration method using ethanol 96% as solvent. Orientation was done with 5 formula mix of powder based on various filler, that is formula I 100% Maltodextrin, formula II 75% Maltodextrin and 25% Avicel PH 102, formula III 50% Maltodextrin and 50% Avicel PH 102, formula IV 25% Maltodextrin and 75% Avicel PH 101, and 100% Avicel PH 102. Mix of powder obtained tested by the physical character including tapping index, compactibility, and mass density of powder. Then is continued with process of tableting in direct compress, tablet obtained it was tested the physical character including Weight uniformity, hardness, friability, and taste test. Antraqinon in extract tested with TLC. The data obtained of tablet testing were analized using T test (P 95%). Result show that formulation of mix powder with higher prosentase Avicel PH 102 have an effect tapping index bigger, mass density of powder smaller, but compactibility test cause variation hardness of each formula. Character of chewable tablet with higher prosentase Avicel PH 102 have an effect weight uniformity more better, tablet hardness go down, friability more higher, and have not an effect significancy with taste comments test. From these research getting result that formula 4 is formula obtain up to standard tablet seen from the physical character of powder and chewable tablet. Result show that extract having glikosida antraqinon. Keyword : Aloe Leaves ( Aloe vera L.), direct compress, formulation

Item Type: Article
Subjects: T Technology > T Technology (General)
Divisions: Faculty of Pharmacy (Fakultas Farmasi) > Pharmacy Doc
Depositing User: Apt Azis Ikhsanudin ikhsanudin
Date Deposited: 10 Jul 2012 04:27
Last Modified: 10 Jul 2012 04:27
URI: http://eprints.uad.ac.id/id/eprint/1401

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