Yuliani, Sapto and Mustofa, Mustofa and Partadiredjac, Ginus (2017) Turmeric (Curcuma longa L.) Extract may Prevent the Deterioration of Spatial Memory and the Deficit of Estimated Total Number of Hippocampal Pyramidal Cells of Trimethyltin-Exposed Rats. Drug and Chemical Toxicology, 41 (1). ISSN ISSN: 0148-0545 (Print) 1525-6014 (Online)
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Abstract
Context: Protection of neurons from degeneration is an important preventive strategy for dementia.
Much of the dementia pathology implicates oxidative stress pathways. Turmeric (Curcuma longa L.) contains curcuminoids which has anti-oxidative and neuro-protective effects. These effects are considered
to be similar to those of citicoline which has been regularly used as one of standard medications for
dementia.
Objective: This study aimed at investigating the effects of turmeric rhizome extract on the hippocampus of trimethyltin (TMT)-treated Sprague-Dawley rats.
Materials and methods: The rats were divided randomly into six groups, i.e., a normal control group
(N); Sn group, which was given TMT chloride; Sn-Cit group, which was treated with citicoline and TMT
chloride; and three Sn-TE groups, which were treated with three different dosages of turmeric rhizome
extract and TMT chloride. Morris water maze test was carried out to examine the spatial memory. The
estimated total number of CA1 and CA2–CA3 pyramidal cells was calculated using a stereological
method.
Results: The administration of turmeric extract at a dose of 200 mg/kg bw has been shown to prevent
the deficits in the spatial memory performance and partially inhibit the reduction of the number of
CA2–CA3 regions pyramidal neurons.
Discussion: TMT-induced neurotoxic damage seemed to be mediated by the generation of reactive
oxygen species and reactive nitrogen species. Turmeric extract might act as anti inflammatory as well
as anti-oxidant agent.
Conclusions: The effects of turmeric extract at a dose of 200 mg/kg bw seem to be comparable to
those of citicoline.
Keywords: Curcuma longa L.; trimethyltin; Morris water maze; pyramidal cell; stereology
| Item Type: | Artikel Umum |
|---|---|
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi) |
| Depositing User: | Dr.drh Sapto Yuliani,MP |
| Date Deposited: | 06 Nov 2019 02:42 |
| Last Modified: | 06 Nov 2019 02:42 |
| URI: | http://eprints.uad.ac.id/id/eprint/15591 |
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