Similarity Check: Efek Kapsul Ekstrak Etanol Kelopak Bunga Rosella (Hibiscus sabdariffa L.) terhadap Kadar Bilirubin Sukarelawan Sehat

Azizah, Nur and Darmawan, Endang and Nurani, Laela Hayu Similarity Check: Efek Kapsul Ekstrak Etanol Kelopak Bunga Rosella (Hibiscus sabdariffa L.) terhadap Kadar Bilirubin Sukarelawan Sehat. Jurnal Farmasi Dan Ilmu Kefarmasian Indonesia.

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Abstract

Background: Hibiscus sabdariffa is one of traditional herbs that has a lot of benefits including immunostimulant effect, because it contains antioxidant compunds including anthocyanin and flavonoid. Based on its activity on preclinical tests, H.sabdariffa has been qualified to proceed to clinical trial phase. Objective: The study aimed to investigate the effect of ethanol extract capsule of rosella petals (Hibiscus sabdariffa L.) on bilirubin levels on 11 healthy male volunteers and 10 healthy female volunteers. Methods: This study used pre-and post treatment design. Healthy volunteers consume ethanol extract capsule of rosella petals for 30 days at a dose of 500 mg once daily at night. Bilirubin test was conducted at day 0; 31 and 45, using Jendrassik and Grof method. Results were analyzed using SPSS with paired t-test and Wilcoxon test. Results: The result showed that the comparison of the mean value at day 0 and 31, with day 31 and 45, and the comparison of the mean value between day 0 and 45 showed no significant difference regarding total and direct (p > 0.05) and indirect bilirubin levels (p = 0.05), but this is still within the normal range of values for indirect bilirubin. Conclusion: The ethanol extract capsule of rosella petals had no affects on total, direct and indirect bilirubin levels in healthy volunteers.

Keywords: ethanol, Hibiscus sabdariffa, bilirubin levels

Item Type:	Other
Subjects:	Z Bibliography. Library Science. Information Resources > ZA Information resources > ZA4050 Electronic information resources
Depositing User:	Dr.rer.nat Endang Darmawan
Date Deposited:	13 May 2020 14:58
Last Modified:	13 May 2020 14:58
URI:	http://eprints.uad.ac.id/id/eprint/18669

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