Proceedings: Evaluation of Formulation of Antidiabetic Herbal Tablet from Andrographis paniculata Ness Leaves

Darmawan, Endang and Mulyaningsih, Sri Proceedings: Evaluation of Formulation of Antidiabetic Herbal Tablet from Andrographis paniculata Ness Leaves. [Artikel Dosen]

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Abstract

Andrographis paniculata Ness (Family: Acanthaceae) has been used for centuries as traditional remedies. The previous study showed that the ethanol extract of A. paniculata had antidiabetic activity and decreased the blood sugar level in rats. The present paper was aime to formulate and to evaluate of the physical features of the herbal tablet of the ethanol extract of A. paniculata. Three different formulations of tablets containing various concentration of avicel were prepared by wet granulation. The micromeritic properties were determined for all the batchs including angle of repose, tapping index and now The angle of repose, tapping index and flow time were found to be in the range of 48-52.11 and 6.5-5.4. respectively. F3 exerted the lowest value of the angle of repose and flow time compared to the other formulas. The tablets were evaluated or weight variation hardness, friability and disintegration time. The maximum weight variation of the tablets was 0.94 to 1.38%. Hardness for tablets of all batches was in the range of 5.0 to 75 kg Friability value for tablets of none of the batch ore than 1.30%. The disintegration time of the tablets F1.F2 and F3 were found about 16.70, 14.27. and 13.24 minutes. The di The result revealed that the tes parameter values (weight variation hardness, friability, and disintegration time) were in eceptable limit based on pharmacopoeial standard.

Item Type:	Artikel Dosen
Subjects:	R Medicine > R Medicine (General)
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > Program of Professional Pharmacist
Depositing User:	Dr.rer.nat Endang Darmawan
Date Deposited:	14 May 2020 14:39
Last Modified:	14 May 2020 14:39
URI:	http://eprints.uad.ac.id/id/eprint/18723

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