Darmawan, Endang and Hidayati, Nurul THE EFFECT OF CELERY AND PHYLLANTUS NIRURY COMBINATION ON URIC ACID LEVEL IN HYPERURICEMIC RATS. [Artikel Dosen]
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Abstract
Hyperuricem Indonesian people. Hyperurice e many research of natural uricemia is a
symptom of gout. Gout is one of pemia is a condition in which blood uric acid is above normal. There
are many of natural sources have been using celery herb (Apium graveolens L.) and meniran herb
(Phyllanthus niruri, L.) as an alternative treatment of hyperuricemia.
Objective: This study was aimed to determine the effect of routine giving combination extract ethanol
celery herb and meniran herb of uric acid in rats experiencing hyperuricemia.
Methods: The 36 rats divided into 6 groups. Group 1 were normal group, group 2 were a positive
control, given allopurinol at dose of 5 mg/kgBW, and negative control 3 were induced potassium
oxonate intraperitoneal and administrated at a dose of 125 mg/kgBW. Groups 4,5 and 6 were given
orally the combination of ethanol extract of celery and P. niruri at ratio of 1:1; 1:3, (dose 20
mg/kgBW), respectively. After given by the extract, 1 hours later induced by potassium oxonate, and
1 hour afterward the blood was taken via orbital sinus. Determination of uric acid levels by enzymatic
methods (Uric Acid TBHBA). The administration of the combination of ex extract ethanol of celery
and P. niruri was given for 7 days at three ratio variation. Blood sampling performed on day 0, 1, 3
and 7. Differences between groups were analyzed statistically by Annova and LSD test (p<0.05).
| Item Type: | Artikel Dosen |
|---|---|
| Subjects: | R Medicine > R Medicine (General) |
| Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > Program of Professional Pharmacist |
| Depositing User: | Dr.rer.nat Endang Darmawan |
| Date Deposited: | 14 May 2020 14:40 |
| Last Modified: | 14 May 2020 14:40 |
| URI: | http://eprints.uad.ac.id/id/eprint/18734 |
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