Similarity Check Antihypercholesterol Activity of Costus Speciosus Water Extract

Susanti, Hari and Wahyuono, Subagus and Puspita Sari, Ika and Asmah Susidarti, Ratna Similarity Check Antihypercholesterol Activity of Costus Speciosus Water Extract. Faculty of Pharmaceutical Sciences, Chulalongkorn University.

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Abstract

Introduction: Hypercholesterolemia is one of the causes of cardiovascular disease. Costus speciosus (CS) is known empirically as an antihypercholesterol remedy. Material and Method: This study was conducted to determine the effect of water extract of CS on cholesterol blood serum level of rat induced-propylthiouracil (PTU). The antihypercholesterol activity performed on male Wistar rats which induced 0.01% PTU (mixed in drinking water, 14 day-induction) was followed by the administration of CS for 14 days. The animals were randomly divided into seven groups: Solvent control (carboxylmethylcellulose 0.5% w/v in water), positive control (simvastatin at dose 7.2 mg/kg BW), negative control (water), CS extract 50, 100, and 200 mg/kg, and normal control. The cholesterol levels were measured at day 0th, 14th, and 28th. Result and Conclusion: Results showed that administration of CS extract 200 mg/kg can reduce the total serum cholesterol equal to simvastatin 7.2 mg/kg.

Item Type:	Other
Subjects:	Q Science > QK Botany R Medicine > RS Pharmacy and materia medica T Technology > TP Chemical technology
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > Program of Professional Pharmacist
Depositing User:	Mrs Hari Susanti
Date Deposited:	01 Oct 2020 04:05
Last Modified:	01 Oct 2020 04:05
URI:	http://eprints.uad.ac.id/id/eprint/20678

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