Budiarto, Setyo and Binarjo, Annas ENHANCEMENT OF PIROXICAM INTRINSIC DISSOLUTION RATE WITH SOLID DISPERSION SYSTEM USING BETA CYCLODEXTRIN. In: International Conference on Drug Development from Natural Resourches.
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Abstract
Objective: This research was aimed to increase the intrinsic dissolution rate (IDR) of
piroxicam with solid dispersion system of piroxicam-betacyclodextrin (SDSPB). This system can
overcome the dissolution problem of piroxicam.
Method: Determination of piroxicam IDR was performed using intrinsic dissolution tester in
100 rpm speed of stir. Free CO2 water was used as solvent. Piroxicam concentration in was
measured using spectrophometer. The piroxicam IDR of SDSPB which was prepared using solvent
method with freeze drying was compared with control (piroxicam alone). Then the interaction of
piroxicam with betacyclodextrin was analyzed using IR spectra.
Result:The IDR of SDSPB and piroxicam pellet are 1.2247 and 0.244 mgcm-2minute-1
respectively. This enhancement was predicted due to inclusion complex and electrostatic interaction
of piroxicam and betacyclodextrin.
Conclusion: The SDSPB can enhance six times fold of piroxicam IDR (p�0,05). The
researches purposed to formulate SDSPB tablet and to test its bioavailability are needed to confirms
this IDR enhancement.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | Q Science > QC Physics Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
| Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi) |
| Depositing User: | Annas arjo Binarjo |
| Date Deposited: | 01 Oct 2015 00:26 |
| Last Modified: | 01 Oct 2015 00:26 |
| URI: | http://eprints.uad.ac.id/id/eprint/2416 |
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