Wahyuningsih, Iis and Utamy, Ekadita and Binarjo, Annas THE INFLUENCE OF PRE-TREATMENT AND CO-TREATMENT OF AMBON BANANA FRUIT JUICE TO FUROSEMIDE BIOAVAILABILITY. In: International Conference on Drug Development from Natural Resourches.
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Abstract
Introduction. Some patients used banana to administered tablet or pill . It is possible that there
will be pharmaceutical interaction between the drug and banana. This study was aimed to know the
influence of pre-treatment and co-treatment of ambon banana fruit juice (Musa paradisiaca L.) on
the furosemide bioavailability..
Method. This study was carried out using cross over design.. The subjects used in this study
were five local male rabbit with same in body weight and divided into 4 treatments. The A group was
treated by furosemide 80 mg (control), The B group was treated by ambon banana fruit juice 100% (5
ml) 2 hours before furosemide administration. The C and D groups were treated by ambon banana
fruit juice 100% and 50% (5 ml) in the same time with furosemide administration. The blood was
taken through marginalis vein of ears at the time 0,5; 0,75; 1; 1,5; 2; 3; 3,5; 4; 8; and 24 hours after
furosemide administration. Furosemide in the blood was determined using Kelly’s method modified
by Hakim. Then, the bioavailability parameters were measured from pharmacokinethics profiles .
Furthermore, t max and Cp max were analized using one-way Anova while AUC0-8 was analized
using Kruskal-wallis.
Result. The average of furosemide bioavailability in male rabbit are Cpmax ; 15,21.10-2
(ìg/ml), 13,97.10-2 (ìg/ml), 11,08.10-2 (ìg/ml), 12,10.10-2 (ìg/ml), tmax; 2,30 hours, 3,50 hours, 3,35
hours , 5,30 hours, and AUC0-8 ; 10,53 ìg.ml-1 hour, 4,00 ìg.ml-1 hour, 4,95 ìg.ml-1 hour, 3,37
ìg.ml-1 hour respectively for treatment A,B,C, and D. There were no significant differences of tmax
and Cpmax and AUC0-8 among groups ( p value> 0.05).
Conclusion. There were no influence of pre-tretment and co-treatment of ambon banana fruit
juice (Musa paradisiaca L.) on the furosemide bioavailability.
| Item Type: | Conference or Workshop Item (Paper) |
|---|---|
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi) |
| Depositing User: | Annas arjo Binarjo |
| Date Deposited: | 01 Oct 2015 00:26 |
| Last Modified: | 01 Oct 2015 00:26 |
| URI: | http://eprints.uad.ac.id/id/eprint/2417 |
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