FORMULATION OF PROPANOLOL CREAM WITH VCO (VIRGIN COCONUT OIL) CONTAINED BASE

Wulandari, Prita Dwi and Binarjo, Annas FORMULATION OF PROPANOLOL CREAM WITH VCO (VIRGIN COCONUT OIL) CONTAINED BASE. In: International Conference on Safety Management of Central Cytotoxic Reconstitution.

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Abstract

Background. Propranolol is a �-blocker agent with low oral bioavailability (15-23%) so that
transdermal route can be used as alternative drug delivery.
Objective. This study was purposed to know the influence of VCO (Virgin coconut Oil) to the
propranolol release rate in cream base preparation.
Methods. Cold cream base in various conentrasion of VCO, i.e 0%(F0), 14%(F1), 28%(F2),
42% (F3) contained 7% propranolol HCl were tested their dissolution using dissolution tester
(paddle shaped stirrer). Acetat buffer solution 0,01MpH 5 was used as medium, the temperature was
set up at 36°C, stiring rate was controlled at 100 rpm. The parameter of this study was DE
(dissolution efficiency) value.
Outcome measured. Dissolution Efficiency value (DE30)
Results. The result showed that DE30 value (in %) of F0, F1, F2, and F3 were 4,73x10-3±0,53
x10-3; 6,41 x10-3±0,63 x10-3; 9,18 x10-3±1,78 x10-3; 12,65 x10-3±2,08 x10-3 respectively.
Conclusion. It can be concluded that VCO increase propranolol dissolution significantly
(p<0,05) and the optimum VCO concentration as cold cream base was 42% with DE30 propranolol
value 267% compare with control formula.

Item Type:	Conference or Workshop Item (Paper)
Subjects:	R Medicine > RL Dermatology R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Annas arjo Binarjo
Date Deposited:	01 Oct 2015 00:26
Last Modified:	01 Oct 2015 00:26
URI:	http://eprints.uad.ac.id/id/eprint/2418

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