In-vitro studies on antioxidant and antidiabetic potential of Sesoot (Garcinia picrorrhiza Miq.) fruit ethanolic extract from Indonesia

Utami, Sri and Pamuji Laksono, Sonny and Romadhiyani Sachrowardi, Qomariyah and Nurul Mustaqimah, Dewi and Endrini, Susi and Andri Damayanti, Ndaru and Nafik, Said and Cendera Arrahmani, Betharie and Sari Widya Kusuma, Hanna and Widowati, Wahyu (2021) In-vitro studies on antioxidant and antidiabetic potential of Sesoot (Garcinia picrorrhiza Miq.) fruit ethanolic extract from Indonesia. Pharmaciana, 11 (2). pp. 273-282.

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Abstract

Diabetes mellitus (DM) is a disease that can be identified by high levels of blood glucose. Garcinia plants have been widely used for many traditional medicines as antioxidant, anticancer, antidiabetics, and antiinflammation. The antioxidant and antidiabetic activities of (Garcinia picrorrhiza Miq.) or sesoot fruit extract were evaluated in this study and compared with xanthone. The antioxidant and antidiabetic of ethanolic ripe sesoot (G. picrorrhiza Miq.) fruit extract (GpKar) was evaluated by (ABTS) reducing activity, α-glucosidase, β-glucosidase, and α-amylase inhibitor activity. GpKar showed higher ABTS-reducing activity (IC50 = 49.30 µg/mL) than xanthone (IC50 = 404.30 µg/mL). GpKar showed IC50 = 109.32 µg/mL for α-glucosidase inhibitory activity, while xanthones had a better activity (IC50 = 33.97 µg/mL). GpKar also showed lower α-amylase inhibitory activity and β-glucosidase (IC50 = 126.01 and 9432.09 µg/mL) compared to xanthone (IC50 = 44.32 and 405.03 µg/mL, respectively). The compounds of GpKar are proven to have antioxidant and antidiabetic activities. Therefore, it will be industrially relevant to develop a natural medicine for decreasing DM risk, thus evaluating the antioxidant and antidiabetic effect of G. picrorrhiza by a pre-clinic study is needed.

Item Type: Artikel Umum
Subjects: R Medicine > RS Pharmacy and materia medica
Divisi / Prodi: Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User: jurnal pharmaciana
Date Deposited: 08 Sep 2021 06:12
Last Modified: 08 Sep 2021 06:12
URI: http://eprints.uad.ac.id/id/eprint/27644

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