Formulation and Antifungal Activity of Piper betle L. Leaf Extract in Emulsion Gels Against Candida albicans

Putranti, Widyasari and Asterina, Chairisty and Witasari, Hardi Astuti (2021) Formulation and Antifungal Activity of Piper betle L. Leaf Extract in Emulsion Gels Against Candida albicans. Majalah Obat Tradisional, 26 (1). pp. 28-34. ISSN ISSN-p : 1410-5918 ISSN-e : 2406-9086

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Abstract

Candidiasis is the most common fungal infection in humans and is a form of primary and secondary
infections of C. albicans. Betel (Piper betle L.) leaf extract has been reported to exhibit efficacious antifungal
effects against C. albicans. Emulsion gels, a type of topical dosage form, can deliver hydrophilic and
hydrophobic drugs and perform multiple and controlled releases. This research aimed to determine the
antifungal activity and physical properties of emulsion gels formulated from betel leaf extract. The dried
betel leaves were extracted by maceration with alcohol 95%. Then, with different concentrations (1, 2, and
4%), the extract was formulated into emulsion gels. These dosage forms were later subjected to antifungal
activity testing against C. albicans using the cup plate diffusion method that involved Mycoral Cream® for
comparison. In this test, the intensity of the activity was determined by measuring the diameter of the
formed inhibition zone. The second test evaluated the physical characteristics of the dosage forms, including
organoleptic properties, pH, adhesion, dispersion, and viscosity. These data were analyzed using the Mann�Whitney method, and the conclusion was withdrawn from describing the results quantitatively. The
reaction yield of the extraction was 9.702%. The analysis results showed that emulsion gels containing 1, 2,
and 4% of betel leaf extract created zones of inhibition with diameters of 5.3 ± 0.29, 6.2 ± 0.29, and 10.2 ±
0.41 mm, respectively. As for the physical properties, they differed in pH (6.39 ± 0.120, 6.17 ± 0.132, 5.66 ±
0.123), spreadability (1.849 ± 0.45, 1.816 ± 0.051, 1.771 ± 0.092 g.cm.s-1), adhesion (110 ± 10.8, 126.3 ± 8.5,
142.7 ± 13.50 seconds), and viscosity (2640.35, 1992.95, 2162.12 cps), respectively. The betel leaf emulsion
gels exhibited antifungal activity against C. albicans (p <0.05) and met the physical requirements of semi�solid dosage forms.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	M.Sc,.Apt Hardi Astuti Witasari
Date Deposited:	11 Jan 2022 02:45
Last Modified:	11 Jan 2022 02:45
URI:	http://eprints.uad.ac.id/id/eprint/31346

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