EFFECTIVENESSAND MECHANISM OFPHYSICIAN HERBSFROM KALI PUTIH BATUR BANJARNEGARA CENTRAL JAVAAGAINSTDIABETIC NEPHROPATHY

Kintoko, Kintoko and Witasari, Hardi Astuti and Kusumo, Djati Wulan and Kapri, Halid and Muldiyana, Tya and Wahyono, Slamet (2018) EFFECTIVENESSAND MECHANISM OFPHYSICIAN HERBSFROM KALI PUTIH BATUR BANJARNEGARA CENTRAL JAVAAGAINSTDIABETIC NEPHROPATHY. EFFECTIVENESSAND MECHANISM OFPHYSICIAN HERBSFROM KALI PUTIH BATUR BANJARNEGARA CENTRAL JAVAAGAINSTDIABETIC NEPHROPATHY, 11 (12). pp. 453-455. ISSN Online - 2455-3891 Print - 0974-2441

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Abstract

Objectives: Complications in the kidneys (nephropathy) are one of the chronic complications of diabetes mellitus (DM) most common microvascular
and estimated to reach 30–40% of all sufferers of DM. Until now there is no cure drug that can prevent diabetic nephropathy. Therefore, the handling
of this issue should be done seriously, one of them through an exploration of drug discovery and drug material. Ristoja in 2015 in the ethnic Javanese
Banyumasan successfully explores the types of plants, herb, and traditional medicine culture. One is conducted by the Kaliputih Traditional Medicine,
Batur, Banjarnegara, Central Java. Based on the results of the interview, traditional medicine has herb for disease therapy kidney failure which consists
of 11 species of plants.
Methods: The herbs were extracted by infundation method. Sprague Dawley albino male rats were divided into 3 groups (normal, positive, and
negative) and 3 sample test groups with 3 different doses (18, 36, and 54 mL/kg body weight [BW]) previously induced streptozotocin. Observations
were carried on the levels blood urea nitrogen (BUN), creatinine, uric acid, and nuclear factor kappa B (NF-κB), cyclooxygenase-2 (COX-2), and
transforming growth factor-beta (TGF-β) kidney immunohistochemically and histology analysis.
Results: Statistical results showed a significant increase of BUN levels in all dose variation groups after being given herbs, compared to the negative
control group. The result of the examination of biochemical parameters of creatinine levels statistic showed significant (p<0.05) decrease in the dose
18 and 36 mL/kg BW compare with the negative group. The result of the study on histopathology kidney organs there are are damages to each test in
each organ that is necrosis. The result of NF-κB, COX-2, and TGF-β expression no significant decrease compared with the negative controls.
Conclusion: The herbs are not capable of nephropathy diabetic and need more research to know that activity as nephroprotective.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	M.Sc,.Apt Hardi Astuti Witasari
Date Deposited:	11 Jan 2022 02:40
Last Modified:	11 Jan 2022 02:40
URI:	http://eprints.uad.ac.id/id/eprint/31351

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