Widyaningsih, Wahyu and Salamah, Nina and Susanti, Hari Peer Review Anti Angionesis Activity of Ethanol Extract of Green Algae (Spyrogyra Sp) Purified with Chorio Allantoic Membrane (Cam) Method. [Artikel Dosen]
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Peer Review - Susanti - antiangiogenesis CAM green algae Spyrogyra Sp.pdf Download (1MB) |
Abstract
Background. Angiogenesis plays an important role in tumor progression. Modern treatment of
cancer currently has an alternative way to inhibit cancer through antiangiogenesis process. It is
expected to inhibit the formation of new blood vessels around the tumor, the supply of nutrients and
oxygen by the blood to the tumor can be inhibited.
Objective. This study aims to determine the antiangiogenesis activity of ethanol extract of
green algae (Spyrogyra Sp) Purified by using the method of chorio allantoic membrane (CAM).
Methods. In this study used 8 groups: Group I was a control that content only paper discs,
paper discs contain a group II + PBS, group III contain a paper disc + PBS + bFGF, group IV, V, VI,
VII, VIII as a treating were given 10, 20, 40, 160, and 320 ug / ml of ethanol extract of green algae
respectively. CAM is Obtained from embryonated chicken eggs aged 8 days. Incubated for 3 days
afterward. The macroscopic observation is used to see the inhibitory activity of blood vessels.
Statictical analysis used Kruskal-Wallis test to compare among each other Significantly, continuated
by Mann Whitney test (P <0.05).
Outcome measured. Inhibitory activity ( IC50)
Results. The results showed that the ethanol extract of green algae purified with concentration
10 ug / ml (p = 0:03) can inhibit angiogenesis of embryonated chicken eggs Compared to bFGF
control.
Conclusion. In conclusion, the ethanol extract of green algae has antiangiogenesis activity in
chorio allantoic membrane.
| Item Type: | Artikel Dosen |
|---|---|
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) T Technology > T Technology (General) |
| Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > Pharmacy Doc |
| Depositing User: | Mrs Hari Susanti |
| Date Deposited: | 20 May 2022 01:57 |
| Last Modified: | 20 May 2022 01:57 |
| URI: | http://eprints.uad.ac.id/id/eprint/32261 |
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