Similarity Check Determination of Ethyl Para Methoxycinnamate Content and Anti-inflammatory test rhizome extract Kaempferia galanga, L by inhibition of protein denaturation method

Nurani, Laela Hayu and Asahi, Aris and Susanti, Hari (2020) Similarity Check Determination of Ethyl Para Methoxycinnamate Content and Anti-inflammatory test rhizome extract Kaempferia galanga, L by inhibition of protein denaturation method. [Artikel Dosen]

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Abstract

Kencur (Kempferia galanga, L) is one of the rhizomes that is often used as a constituent component in traditional medicinal formulas. One of the kencur's pharmacological activities is anti-inflammatory. The active compound as an anti-inflammatory is ethyl p-methoxycinnamate (EPMC). This study aims to determine the content and ascertainment of EPMC compounds and the anti-inflammatory activity of kencur rhizome extract. Kencur extract can be obtained by the maceration method using 96% ethanol solvent. The EPMC content determination was held using the TLC-densitometry method, while the EPMC compounds were confirmed using the GC MS method. The anti-inflammatory activity test was done using inhibiting protein denaturation methods. The extract results obtained 12.67% yield. The result of EPMC content in kencur extract was 10.05 ± 4.57. The GCMS kencur extract results showed an abundance of EPMC compounds at a retention time of 7.088 with a peak area of 72290779. The results of IC50 anti-inflammatory for the standard substance (EPMC) were 5.306 ± 5.028. The results of IC50 anti-inflammatory the sample (kencur extract) was 303.487 ± 1.201. Ethanol extract of kencur contains ethyl p-methoxycinnamate (EPMC) and has anti-inflammatory activity by inhibiting protein denaturation.

Item Type: Artikel Dosen
Subjects: Q Science > Q Science (General)
R Medicine > R Medicine (General)
R Medicine > RS Pharmacy and materia medica
Divisi / Prodi: Faculty of Pharmacy (Fakultas Farmasi) > Pharmacy Doc
Depositing User: Mrs Hari Susanti
Date Deposited: 20 May 2022 03:10
Last Modified: 20 May 2022 03:10
URI: http://eprints.uad.ac.id/id/eprint/35016

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