Hasil cek simmilarity_Hepatoprotective effect of chewable tablet of Centella asiatica (L.) Urb extractin Wistar rats induced by highat diets

Akrom, Akrom and Hastanto, Feri Anggita and Nurani, Laela Hayu (2021) Hasil cek simmilarity_Hepatoprotective effect of chewable tablet of Centella asiatica (L.) Urb extractin Wistar rats induced by highat diets. Indonesian Journal of Pharmacology and Therapy, 2 (1). ISSN 2745-455X

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Abstract

Gotukola or Centella asiatica (L.) Urban contains high flavonoids which well
known as fatty liver protector. This study aimed to evaluate the hepatoprotective
effect of chewable tablet of C. asiatica (L.) Urb extract (CTCE) in Wistar rats
induced by high fat diets. Twenty-one Wistar male rats aged 8-12 weeks with
body weight ranging from 100-150 g were used in this study. Rats were randomly
divided into seven groups i.e. Group 1 as normal control, rats were given standard
food, Group 2 as high fat diets control, rats were induced high fat diets (HFD),
Group 3 as positive control, rats were induced HFD and given simvastatin, Group
4 as placebo control, rats were induced HFD and given placebo, Group 5-7 as
treatment group, rats were induced HFD and given CTCE at doses of 100, 200 and
300 mg/kg BW, respectively. The HFD induction was conducted for five weeks and
the CTCE was given for one week in the last week of the induction. At the end of
the intervention, blood triglyceride levels and SGPT as well SGOT activities were
examined. Analysis of variance (ANOVA) with confidence interval of 95% (p<0.05)
was applied. The results showed that the HFD induction increased the serum
triglyceride levels and SGPT activity. The serum triglyceride levels and SGPT
activity of Group 2 were significantly higher than Group 1 (p<0.05). Furthermore,
the simvastatin and CTCE administration reduced the serum triglyceride levels
and SGPT activity. The serum triglyceride levels and SGPT activity of Group 3, 5, 6
and 7 were significantly lower than Group 2 and 4 (p<0.05). In addition, the serum
triglyceride levels and SGPT activity of Group 5, 6 and 7 were significantly lower
than Group 3 (p<0.05). In conclusion, CTCE can reduce the serum triglyceride
levels and SGPT activity in Wistar rats induced by HFD.

Item Type:	Artikel Umum
Subjects:	Z Bibliography. Library Science. Information Resources > Z665 Library Science. Information Science
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Akrom Akrom
Date Deposited:	15 Jun 2022 02:25
Last Modified:	15 Jun 2022 02:31
URI:	http://eprints.uad.ac.id/id/eprint/35328

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