Akrom, Akrom and Mustofa, Mustofa and Nurani, Laela Hayu (2021) Hasil cek similarity" Ethanolic Extract of Black Cumin Seed Reduced Radical Reactive from Dimethylbenzanthracene Compounds". IOP Publishing, Sriwijaya International Conference on Earth Science and Environmental, IOP Conf. Series: Earth and Environmental Science 810 (2021) 012037.
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HASIL CEK_Ethanolic Extract of Black Cumin Seed Reduced Radical Reactive from Dimethylbenzanthracene Compounds.pdf Download (2MB) |
Abstract
Dimethylbenzantracene is a compound that is radical reactive, genotoxic, and immunotoxic.
Black cumin seeds have antioxidative properties. The study aimed to determine the effect of the black
cumin seed ethanolic extract as an antioxidant by observing the secretion activity of ROI and NO
peritoneal macrophages in Sprague Dawley (SD) rats induced by DMBA. This controlled experiment
used 30 male SD rats. The test animals were randomly divided into six groups. Group I was given
standard food and drink. Group II was given DMBA. Groups III, IV, and V were given EEBCS doses
of 5, 25, and 125 mg orally for seven weeks, respectively. Group VI was given Imboost. From week 3
to week seven, all test animals were induced 10x20 DMBA, 2x per week.At week 16, all test animals
were sacrificed and isolated and cultured peritoneal macrophage cells. The activity of ROI secretion
and NO macrophage secretion was tested. Data on ROI secretion and NO levels were tested for
ANOVA, followed by LSD test with a confidence level of 95%. The results showed that DMBA
induction increased ROI secretion by macrophages and decreased NO.EEBCS secretion decreased
ROI secretion and grew NO. The DMBA group had the lowest NO levels. This study concluded that
EEBCS at doses 5 and 125 reduced the flow of ROI peritoneal macrophages in SD rats induced by
DMBA but reduced NO levels.
| Item Type: | Other |
|---|---|
| Subjects: | R Medicine > RS Pharmacy and materia medica |
| Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi) |
| Depositing User: | Laela |
| Date Deposited: | 18 Jun 2022 03:33 |
| Last Modified: | 18 Jun 2022 03:33 |
| URI: | http://eprints.uad.ac.id/id/eprint/35396 |
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