Santoso, Arif and Hidayati, Titiek and Akrom, Akrom and Nurani, Laela Hayu (2021) Hasil similarity cek_The Effect of Black Cumin Seed Oil on Alanine Aminotransferase Levels which are Influenced by Nutritional Status in Active Smokers. Jurnal Farmasi Indonesia.
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HASIL CEK_Santoso, Hidayati, Akrom, Nurani_Active smokers, ALT, BCSO, folic acid, randomized controlled trial, vitamin C. (1).pdf Download (2MB) |
Abstract
Black cumin seed oil (BCSO) has the main compound thymoquinone which is thought to
have hepatoprotective activity through an antioxidant mechanism. Exposure to
cigarette smoke can cause cellular oxidative stress which is the key to the inflammatory
process of liver cells and an increase in the activity of the Alanine aminotransferase
(ALT) enzyme. Vitamin C and folic acid are nutrients that affect ALT levels through
antioxidant activity. The main objective of this study was to see the effect of BCSO
administration on ALT levels which were influenced by the intake of vitamin C and folic
acid in healthy respondents who were active smokers for 30 days. This study used a
single-blind Randomized Controlled Trial (RCT) method, with a total of 39 test subjects
divided into four groups. Group 1 received 3x1 placebo, group 2 received BCSO 3x1,
group 3 received BCSO 3x2, group 4 received BCSO 3x3. Investigation based on the
ANOVA test, it turned out that there was no significant difference in the mean ALT
levels in both the placebo group and the treatment group with p value = 0.452. For the
p value of the intake of vitamin C and folic acid were 0.359 and 0.669, respectively.
Based on the results of the study showed that the administration of BCSO for 30 days
had no significant effect on the average activity of ALT in healthy active smokers and
there was no significant difference in the intake of vitamin C and folic acid.
| Item Type: | Other |
|---|---|
| Subjects: | Z Bibliography. Library Science. Information Resources > Z665 Library Science. Information Science |
| Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi) |
| Depositing User: | Akrom Akrom |
| Date Deposited: | 21 Jun 2022 02:14 |
| Last Modified: | 21 Jun 2022 02:14 |
| URI: | http://eprints.uad.ac.id/id/eprint/35456 |
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