Akrom, Akrom and Darmawan, Endang and Maulida, Nuril and syuhada, syuhada (2021) Bukti Review Artikel_Antioxidants and immunomodulatory effect of black cumin seed oil in at-risk metabolic syndrome. Bali medical Journal, Universitas Udayana.
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Abstract
Introduction: Black Cumin Seed Oil (BCSO) is a traditional medicine widely used as an antioxidant and immunomodulator.
Objective: The purpose of this study is to investigate the effect of dose variation of BCSO (1.5 ml/day versus 3 ml/day) on IL-10
activity and MDA levels in patients at risk of MS at Jetis 1 Public Health Center (J1PHC), Bantul Regency, Yogyakarta, Indonesia.
Methods: We conducted an analytical cross-sectional study. 66 patients at risk of metabolic syndrome (MS) were divided into
two groups. In stage 1, group 1 received a 1.5 ml/day dose, and group 2 received 3 ml/day for 20 days. The clinical parameters
of MS, IL-10 activity, and MDA levels were measured at the end of the study stages.
Results: The mean activity of IL-10 in the 1.5 ml/day dose group was 4.83 and in the 3 ml/day dose group was 5.49, which
showed an increase of around 13.66% (p = 0.300). The mean MDA level in the 1.5 ml/day group was 3.92 μmol/L, which
increased to 4.31 μmol/L in the 3 ml/day group or approximately 9.95% (p = 0.802). Statistically, IL-10 activity and MDA
levels in the two-dose groups did not differ significantly.
Conclusion: The results of this study indicate that the administration of BCSO at doses of 1.5 ml/day and 3 ml/day for 20 days
has the same effect on IL-10 activity and MDA levels in patients at risk of MS.
| Item Type: | Other |
|---|---|
| Subjects: | Z Bibliography. Library Science. Information Resources > Z665 Library Science. Information Science |
| Divisi / Prodi: | Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi) |
| Depositing User: | Akrom Akrom |
| Date Deposited: | 28 Jun 2022 01:47 |
| Last Modified: | 28 Jun 2022 01:47 |
| URI: | http://eprints.uad.ac.id/id/eprint/35582 |
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