Similarity Results for Bioprocess Potentials of Squalene from Thraustochytrids Microalgae for Nutraceuticals in New Normal Era Isolated from Indonesian Mangroves: A Review)

suhendra, suhendra and Sulistiawati, Endah and Evitasari, Rachma Tia (2021) Similarity Results for Bioprocess Potentials of Squalene from Thraustochytrids Microalgae for Nutraceuticals in New Normal Era Isolated from Indonesian Mangroves: A Review). CHEMICA : Jurnal Teknik Kimia, 8 (1). pp. 18-31. ISSN 2355-8776

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Abstract

The covid-19 pandemic has been increasing people's awareness of good
habits to maintain their health. Accordingly, the choice shifted more to
consume nutraceutical and functional food to provide a beneficial
impact. One of the essential and attractive nutraceuticals is squalene
(C30H50) which has a long history the biosynthesis of cholesterol,
vitamins and steroid hormones in human. A common raw material to
produce squalene comes from the liver oil of a deep-sea shark.
However, the strategy to use liver sharks in squalene production
encountered environmental and political barriers due to strict nature
protection regulations. The renewed scientific interest has found
microalgae from the thraustochytrids family as a promising future
source of squalene. Thraustochytrids is a group of osmo-heterotrophic
marine microalgae, which can be found commonly in mangrove area..
As the country with the largest mangrove forest globally, Indonesia has
the highest biodiversity potentials of Thraustochytrids. Unfortunately,
the study on the potential of Thraustochytrids microalgae from
Indonesian mangrove forests for squalene production has received less
attention from researchers. Therefore, this paper presents
Thraustochytrids' potential from Indonesian mangrove forests as a
sustainable source of squalene production that can replace raw
material from shark liver oil. This paper summarizes all selected strains
used in the previous study and their operating parameters. Based on our
review study Aurantiochytrium sp. 18W-13a–1 is the most productive
Thraustochytrids which produced 0.32 g/L.day in the nutrients of 2.0%
glucose, 1.0% tryptone, 0.5 g/l yeast, and 50% artificial seawater
(ASW). Compared to squalene from other sources (yeast, bacteria, and
plants), Thraustochytrid can yield more squalene. Bioprocess
engineering aspects and the general uses of squalene are also
presented, including the notable developments in the adjuvant vaccine
of Covid-19, anti-aging substance, and anti-cancer applications.

Item Type:	Artikel Umum
Subjects:	T Technology > TP Chemical technology
Divisi / Prodi:	Faculty of Industrial Technology (Fakultas Teknologi Industri) > S1-Chemical Engineering (S1-Teknik Kimia)
Depositing User:	Rachma Tia Evitasari
Date Deposited:	03 Oct 2022 08:30
Last Modified:	03 Oct 2022 08:30
URI:	http://eprints.uad.ac.id/id/eprint/37196

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