Hasil cek similarity" Effect of ethanolic extract of rosella(Hibiscus sabdariffa L.) on vital signs, kidney, and liver safety (ahead of print)"

Nurani, Laela Hayu and Darmawan, Endang and Akrom, Akrom and Guntarti, Any and Warsi, Warsi and Ariani Edityaningrum, Citra and Harun, Nurhidayati and Mardhiyani, Dini and Azizah Syahrana, Nur and Azizah, Nur and Setianingsih, Siti and Rohman, Abdul (2022) Hasil cek similarity" Effect of ethanolic extract of rosella(Hibiscus sabdariffa L.) on vital signs, kidney, and liver safety (ahead of print)". Herba Polonica, 68 (3).

Text HASIL CEK_Nurani,Darmawan,Akrom,Guntarti,Warsi,Edityaningrum_leukocytes, lymphocytes, BUN, SGOT, SGPT, Hibiscus sabdariffa (1).pdf Download (2MB)

Abstract

Introduction: Rosella (Hibiscus sabdariffa L) extract is often used as immune-stimulant because it contains
flavonoids, especially anthocyanin and quercetin with antioxidant activities. Objective: This study aimed to determine the safety of the rosella extract consumed in the form of capsules
on the vital signs, haematologic parameters as well as kidney and liver function.
Methods: This research was conducted using clinical trial pre- and post-test design in healthy participants.
There were 21 healthy participants (52% male, age ranged 8–45) consuming rosella capsules for thirty days,
in a dose of 500 mg extract daily. Leukocytes, lymphocytes, blood urea nitrogen (BUN), serum glutamic
oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and vital signs were consecutively
evaluated on days 0, 31, and 45, respectively. The Wilcoxon and paired sample t-test were used to
compare the parameters among the evaluated times.
Results: The result showed that no significant difference for all parameters among the three time points
(p>0.05).
Conclusion: These findings suggested that the administration of ethanolic extract of rosella is potential
safe and does not negatively affect the vital signs, haemoglobin, leukocytes, lymphocytes, BUN, SGOT, and
SGPT.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User:	Laela
Date Deposited:	27 Oct 2022 06:35
Last Modified:	27 Oct 2022 06:35
URI:	http://eprints.uad.ac.id/id/eprint/37368

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