Bukti cek similaritas IJP 2022 : The Antihyperlipidemic Effect of Purple Sweet Potato Leaf Extract (Ipomoea batatas L.) and Red Yeast Rice Combination on Hypercholesterol Rats

Sulistyani, Nanik (2022) Bukti cek similaritas IJP 2022 : The Antihyperlipidemic Effect of Purple Sweet Potato Leaf Extract (Ipomoea batatas L.) and Red Yeast Rice Combination on Hypercholesterol Rats. Indonesian Journal of Pharmacy, 33 (1). ISSN 2338-9427

Text HASIL CEK_Mahfudz, Mantali, Sulityani_ Antihyperlipidemic, Antioxidant, Sweet Potato Leaf, Red Yeast Rice (1).pdf Download (1MB)

Abstract

Hyperlipidemia is a condition in which lipids in the blood, such as cholesterol and triglycerides, are present in a high level, causing a variety of other diseases. This condition also causes an increase in free radicals, resulting in oxidative stress. Purple sweet potato leaves and red yeast rice have been reported to have antihyperlipidemic and antioxidant activity in several studies. This particular study aimed to examine the effect of the combination of purple sweet potato leaf extract and red yeast rice on cholesterol and triglyceride levels as well as malondialdehyde(MDA) levels and to examine glutathione peroxidase (GPx) activity on rats induced with a high-fat diet. The experimental animals were randomly divided into 6 groups of 5 mice each: group 1being the normal group; group 2 being the positive control; group 3 being the negative control; group 4 being treated with purple sweet potato leaf extract at 400 mg/kg BW; group 5 being treated with red yeast rice at 40 mg/kg BW; and group 6 being treated with a combination of purple sweet potato leaf extract and red yeast rice at 360 mg/kg BW and 40 mg/kg BW, respectively. The rats were given high-fat feed for 28 days, and on days 15–28 they were also given oral preparations. At the end of the study, allthe rats were blood drawn to measure their cholesterol and triglyceride levels. The rats were then sacrificed, and the liver was taken to measure their MDA and glutathione peroxidase levels. The administration of purple sweet potato leaf extract (group 4), red yeast rice (group 5), and their combination (group 6) significantly (p < 0,05) reduced cholesterol, triglyceride, and MDA levels and increased GPx activity. This finding shows that the combination of purple sweet potato leaf extract and red yeast rice had antihyperlipidemic and antioxidant activity in hypercholesterol rats.

Item Type:	Artikel Umum
Subjects:	A General Works > AC Collections. Series. Collected works
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > Pharmacy Doc
Depositing User:	Dr Nanik Sulistyani
Date Deposited:	14 Nov 2022 03:54
Last Modified:	14 Nov 2022 03:54
URI:	http://eprints.uad.ac.id/id/eprint/37506

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