Similarity_Fractionation of a phenolic compound from water spinach (Ipomoea aquatica) herbs as anti-dandruff against Malassezia sp.

Kintoko, Kintoko (2022) Similarity_Fractionation of a phenolic compound from water spinach (Ipomoea aquatica) herbs as anti-dandruff against Malassezia sp. Pharmaciana, 12 (3). pp. 358-363. ISSN ISSN:2088-4559,e-ISSN:2477-0256

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Abstract

Dandruff is a scalp disorder caused by a fungus (Malassezia sp.). Water spinach (Ipomoea
aquatica) contains phenolic compounds which have antifungal activity. The purpose of this

research is to know the active fraction of water spinach (Ipomoea aquatica) herbs that have an anti-
dandruff activity against Malassezia sp. The study used a true experimental design for an anti-
dandruff activity test. Fractionation of water spinach (Ipomoea aquatica) methanol extracts used

column chromatography which stationary phase with silica gel 60 powder and mobile phase with
chloroform: ethanol: acetyl acetate (8:2:0,1). In vitro anti-dandruff activity based on minimum
inhibitory concentration (MIC) and minimum antifungal concentration (MFC) against Malassezia
sp. of human dandruff isolate. The average of MIC and MFC among groups fraction of water
spinach (Ipomoea aquatica) methanol extracts compared used Friedman test (p≤ 0,05).
Fractionation produces 12 fractions, and fraction number 7 of water spinach (Ipomoea aquatica)
herbs have the best anti-dandruff activity against Malassezia sp. with MIC 125 μg/mL and MFC
250 μg/mL identified as a phenolic compound. Based on the results, a fraction of phenolic
compounds from water spinach (Ipomoea aquatica) herbs have anti-dandruff activity against
Malassezia sp.

Item Type:	Artikel Umum
Keyword:	Malassezia sp., phenolic compound, water spinach (Ipomoea aquatica) herbs, antidandruff
Subjects:	R Medicine > R Medicine (General)
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Kintoko Kintoko
Date Deposited:	03 Dec 2022 01:19
Last Modified:	03 Dec 2022 01:23
URI:	http://eprints.uad.ac.id/id/eprint/37796

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