Investigation of susceptibility genes for chickenpox disease across multiple continents

Irham, Lalu Muhammad and Adikusuma, Wirawan and Lolita, Lolita and Puspitaningrum, Anisa Nova and Afief, Arief Rahman and Sarasmita, Made Ary and Dania, Haafizah and Khairi, Shabiah and Djalilah, Gina Noor and Purwanto, Barkah Djaka and Cheung, Rocky (2022) Investigation of susceptibility genes for chickenpox disease across multiple continents.

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Abstract

Chickenpox (varicella) is caused by infection with the varicella-zoster virus (VZV), a neurotropic alpha herpes
virus with a double-stranded DNA genome. Chickenpox can cause life-threatening complications, including
subsequent bacterial infections, central nervous system symptoms, and even death without any risk factors. Few
studies have been reported to investigate genetic susceptibility implicated in chickenpox. Herein, our study
identified global genetic variants that potentially contributed to chickenpox susceptibility by utilizing the
established bioinformatic-based approach. We integrated several databases, such as genome-wide association
studies (GWAS) catalog, GTEx portal, HaploReg version 4.1, and Ensembl databases analyses to investigate
susceptibility genes associated with chickenpox. Notably, increased expression of HLA-S, HCG4P5, and ABHD16A
genes underlie enhanced chickenpox susceptibility in the European, American, and African populations. As
compared to the Asian population, Europeans, Americans, and Africans have higher allele frequencies of the
extant variants rs9266089, rs10947050, and rs79501286 from the susceptibility genes. Our study suggested that
these susceptibility genes and associated genetic variants might play a critical role in chickenpox progression
based on host genetics with clinical implications.

Item Type: Artikel Umum
Subjects: R Medicine > RM Therapeutics. Pharmacology
Divisi / Prodi: Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User: Lalu Muhammad Irham, M.Farm., Ph.D
Date Deposited: 02 Jan 2023 05:18
Last Modified: 02 Jan 2023 05:18
URI: http://eprints.uad.ac.id/id/eprint/38370

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