Hasil cek similarity " Aktivitas Ekstrak Rimpang Kunyit (Curcuma longa L) pada Mencit Parkinson yang Diinduksi Haloperidol"

Yuliani, Sapto and Bachri, Moch. Saiful and Widyaningsih, Wahyu and Sofia, Vivi and Muttaqien, Dandy Annas and Putri, Galuh Rista and Putri, Nadia Selvia and Rahmadita, Sofina and Rahmita, Intan Dwi (2022) Hasil cek similarity " Aktivitas Ekstrak Rimpang Kunyit (Curcuma longa L) pada Mencit Parkinson yang Diinduksi Haloperidol". Universitas Gadjah Mada.

Text Hasil Cek _Activity of Turmeric Rhizome Extract (Curcuma longa L) in Haloperidol-Induced Parkinson’s Mice.pdf Download (2MB)

Abstract

Parkinson’s disease is a neurodegenerative disease with motor disorders such as bradykinesia, rigidity, and tremors that can affect body balance. This happens because of a decrease in dopamine levels that can be triggered by oxidative stress. Turmeric (Curcuma longa) contains curcumin which has potential antioxidative and neuroprotective activity so that it can prevent neurodegenerative disorders due to oxidative stress. The purpose of this study was to determine the activity of turmeric rhizome extract in haloperidol-induced Parkinson’s model mice. Extraction of turmeric rhizome was carried out by maceration with 96% ethanol as solvent. A total of 60 mice were divided into 6 groups, each of which was treated as follows: The normal group was given CMC-Na orally (po) and 0.9% NaCl intraperitoneally (ip), the haloperidol group was given CMC-Na (po) and haloperidol solution ip (1 mg/kg BW), the levodopa group was given levodopa (po) and haloperidol solution, the extract groups were given turmeric extract at a dose of 100, 200 and 400 mg/kg BW and haloperidol ip. The treatments were given for 21 days. Fifteen minutes after the last day of treatment, all mice except group 1 were injected with haloperidol at a dose of 1 mg/kg BW by i.p. Then the rod test, spinning wheel test, geotactic reflex test, cliff avoidance reflex test and olfactory ability test were carried out at minutes 5, 60, 120 and 180. The data obtained were analyzed using a one-way ANOVA test followed by a post hoc LSD test. The results of data analysis showed that the administration of haloperidol could increase the catalepsy time, increase the number of falls and accelerate the first fall time, decrease the geotactic reflex, increase the avoidance reflex time and decrease the sense of smell. While the administration of turmeric extract doses of 200 and 400 mg/kgBW can reduce catalepsy time, reduce the number of falls and prolong the time of first falling, reduce geotactic reflexes, decrease the length of time on the avoidance reflex test and improve the ability of the sense of smell when compared to Haloperidol (P< 0.05). The administration of 200 and 400 mg/kg extracts was not significantly different (P>0.05) with levodopa administration. Based on the results, it can be concluded that turmeric rhizome extract doses of 200 and 400 mg/kgBW have activity to prevent Parkinson’s in mice given haloperidol.
Key words : Curcuma longa L; Haloperidol; Parkinson

Item Type:	Other
Subjects:	R Medicine > RM Therapeutics. Pharmacology
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > Program of Professional Pharmacist
Depositing User:	Moch. Saiful Bachri
Date Deposited:	06 Jan 2023 01:22
Last Modified:	06 Jan 2023 01:22
URI:	http://eprints.uad.ac.id/id/eprint/38455

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