Herbal Honey Preparations of Curcuma Xanthorriza and Black Herbal Honey Preparations of Curcuma Xanthorriza and Black Cumin Protect against Carcinogenesis through Antioxidant and Immunomodulatory Activities in Sprague Dawley (SD) Rats Induced with Dimethylbenz(a)anthracene

Hidayati, Titiek and Akrom, Akrom and Darmawan, Endang and Indrayanti, Indrayanti (2023) Herbal Honey Preparations of Curcuma Xanthorriza and Black Herbal Honey Preparations of Curcuma Xanthorriza and Black Cumin Protect against Carcinogenesis through Antioxidant and Immunomodulatory Activities in Sprague Dawley (SD) Rats Induced with Dimethylbenz(a)anthracene. Nutrients, 15 (2). ISSN EISSN 2072-6643

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Abstract

Traditionally, Curcuma xanthorriza (CX), black cumin seed (BC), and honey
have been used by the Indonesian people as medicinal ingredients to treat various health symptoms.
CX extracts and BC have been proven in the laboratory as chemopreventive agents, antioxidants,
and immunomodulators. In this study, we developed CX extract, BC oil, and honey into herbal
honey preparations (CXBCH) and hypothesized that the preparations show chemopreventive activity. The purpose of the study was to determine the CXBCH potential as chemopreventive, antioxidant, and immunomodulatory. Method: In this experimental laboratory research, antioxidant,
immunomodulatory, and cytotoxic activities were tested on human mammary cancer cell lines
(T47D cells) while the chemopreventive activity of the CXBCH preparations on Sprague Dawley
(SD) rats induced with dimethylbenzene(a)anthracene (DMBA). Results: CXBCH preparations
demonstrated immunomodulatory, antioxidant, and cytotoxic activities in T47D, Hela, and HTB183 cells and in DMBA-induced SD rats, as the preparations inhibited tumor nodule formation, increased the number of CD4, CD8 and CD4CD25 cells, and glutathione-S-transferase (GST) activity,
and decreased serum NO levels. Conclusions: CXBCH preparations display chemopreventive, antioxidant, and immunomodulatory properties.

Item Type:	Artikel Umum
Subjects:	Z Bibliography. Library Science. Information Resources > Z665 Library Science. Information Science
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User:	Akrom Akrom
Date Deposited:	26 Jan 2023 03:43
Last Modified:	26 Jan 2023 03:43
URI:	http://eprints.uad.ac.id/id/eprint/39160

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