Hasil Similarity_Hemogram results and renal function before and after administration of black cumin seed oil in healthy volunteers

Akrom, Akrom and Hidayati, Titiek and Sagiran, Sagiran and Indrayanti, Indrayanti (2022) Hasil Similarity_Hemogram results and renal function before and after administration of black cumin seed oil in healthy volunteers. Thai Journal of Pharmaceutical Sciences, 46 (3). ISSN E-ISSN(s) : 1905-4637; P-ISSN(s): 0125-4685

Text Cek Similarity_Hemogram results and renal function before and after administration of black cumin seed oil in healthy volunteers.pdf Download (1MB)

Abstract

Black cumin seed oil (BSCO) is widely used to maintain health and strengthen the people of
Indonesia’s immune system and proved to be safe for kidneys. However, the effect of BSCO usage
in a healthy kidney is remaining unknown. This study was aimed to determine the impact of
the 20-day administration of BCSO on kidney function in healthy volunteers. We conducted a
pre- and post-control design trial in 36 healthy volunteers. The volunteers had to hold a valid
health certificate from the hospital, be willing to be involved in the research as evidenced by their
willingness to complete and sign an informed consent, and be aged between 18 and 50 years.
Pregnant women and participants allergic to BCSO were excluded from the study. BCSO was given
for 20 days in three dose regimes: 3 × 1, 3 × 2, and 3 × 3 capsules/day. Blood pressure, pulse,
weight, and blood chemistry of kidney function was observed, and hemograms and urinalyses
were performed before and after treatment. One-way ANOVA and a repeated measures analysis
were used to examine the mean difference of clinical parameters outcomes. BCSO administration
with the three-dose levels for 20 days did not change blood pressure, hemogram, blood urea
levels, blood creatinine levels, or specific gravity and urine pH (P > 0.05). Based on the result, it
can be concluded that the administration of BCSO for 20 days in healthy volunteers has not been
able to show its effect on kidney function. It is necessary to plan a study with a longer duration
and a higher dose to determine the effect of BCSO on the kidney function.

Item Type:	Artikel Umum
Subjects:	Z Bibliography. Library Science. Information Resources > Z665 Library Science. Information Science
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User:	Akrom Akrom
Date Deposited:	26 Jan 2023 03:50
Last Modified:	26 Jan 2023 03:50
URI:	http://eprints.uad.ac.id/id/eprint/39163

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