Formulation of Sechium edule Extract Effervescent Granule with the Variation of Citric Acid, Tartrate Acid and Sodium Bicarbonate

Grajang, Ina Ba’dia and Wahyuningsih, Iis Formulation of Sechium edule Extract Effervescent Granule with the Variation of Citric Acid, Tartrate Acid and Sodium Bicarbonate. Proceedings of the 1st Muhammadiyah International Conference on Health and Pharmaceutical Development (MICH-PhD 2018).

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Abstract

The Sechium edule fruit is traditionally proven to contain antiulcer. Thus, it is necessary to develop dosage
formulations. An effervescent granule is chosen as an alternative form of drug delivery, considering its
dosage preparation may apply simply within a short amount of time. This study aims to discover the
composition of the mixture of citric acid, tartrate acid, and sodium bicarbonate met the physical test
requirement for effervescent granule. Effervescent granules are made by wet granulation technique (the
mixture of alkali-acid) by <25% of relative humidity on 20-25oC temperature. There are three effervescent
granule formulas, consisting a different portions composition of citric acid, tartrate acid, and sodium
bicarbonate: formula I = (2.5 :5:15); formula II = (2.25:4.5:16.88); and formula III = (2:4:18). Physical test
on granules consists of flow rate test, moisture content, time of dissolution, pH and organoleptic. Following
trials performed on Formulas I, II, and III of effervescent granule, the granules flow time of each formula
are:1.48;1.53;1.48 seconds moisture content: 3.40; 3.62; 3.50%, time of solubility : 4.37; 4.25; 3.65 minutes,
pH: 6.62; 6.54; 6.59, and likeness survey: (Colour=1.93; 1.90;2,0.Scent=2.0; 1.93; 2.07. Flavour=1.76; 2.06;
2.13). Those three formulas met the good physical test requirement, except on the moisture content.
Formula III go the most preference on colour, scent and taste.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	Iis Wahyuningsih
Date Deposited:	30 Mar 2023 02:08
Last Modified:	30 Mar 2023 02:08
URI:	http://eprints.uad.ac.id/id/eprint/41776

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