Evaluation and clinical activity test of various concentrations of peel-off gel mask of robusta coffee seed extract (Coffea canephora) as anti-aging

Yasir, Angga Saputra and Renita, Agesta Yesti and Tutik, Tutik (2023) Evaluation and clinical activity test of various concentrations of peel-off gel mask of robusta coffee seed extract (Coffea canephora) as anti-aging. Pharmaciana, 13 (1). pp. 87-99. ISSN ISSN:2088-4559,e-ISSN:2477-0256

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Abstract

Robusta coffee beans contain antioxidant compounds having anti-aging properties. This study aims to determine the content of secondary metabolites in robusta coffee bean extract, anti-aging effectiveness, and the best peel-off gel mask preparation concentration. The extraction method in this study used maceration with 96% ethanol as solvent. The extraction results were carried out by phytochemical screening and formulation of peel-off gel mask preparations, then tested for anti-aging effectiveness using 12 female volunteers and observed signs of aging, including pores, spots, wrinkles, and moisture for four weeks. Robusta coffee bean extraction results obtained a yield of 9.2%. The results of phytochemical screening showed that robusta coffee bean extract contains flavonoid compounds, alkaloids, tannins, and saponins. The results of the evaluation of the 0.5% formula of robusta coffee bean extract were the most preferred by volunteers. The best effectiveness and concentration test results were found in the peel-off gel mask preparation of 2% robusta coffee bean extract formula (F2) compared to blank and F1 (p-value <0.05). The percentage of improvement in the condition of the volunteers' skin, including pores, spots, wrinkles, and moisture, is 21.88  4.22%, 21.57  3.25%, 17.71  2.44%, and 21.25  3.62%, respectively.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	15 Apr 2023 03:55
Last Modified:	15 Apr 2023 03:55
URI:	http://eprints.uad.ac.id/id/eprint/42840

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