Anti-inflammatory activity of Indonesian nutmeg seeds (Myristica fragrans Houtt): A topical gel formulation

Azis, Ikhsanudin and Lolita, Lolita Anti-inflammatory activity of Indonesian nutmeg seeds (Myristica fragrans Houtt): A topical gel formulation. [Artikel Dosen]

Text Anti-inflammatory activity of Indonesian nutmeg seeds.pdf Download (382kB)

Abstract

Herbal medicines have been shown as anti-inflammatory with potentially
lesser side effects. The active compound of nutmeg seed is proven to
accelerate the healing process of inflammation. This study aimed to evaluate
the gel formulation of Indonesian nutmeg (Myristica fragrans Houtt) seed
extract for anti-inflammatory activity. A true experimental post test only with
control group design was used in this study. The gel was formulated with
various concentrations of nutmeg seed extract, namely formulations F1 (0%),
F2 (2%), F3 (4%), F4 (8 %), and F5 (12%). Analysis of variance (ANOVA)
followed by the least significant difference (LSD) methods were performed
with SPSS version 22. The results showed that all formulas had an opaque
physical appearance, brownish-yellow color, soft texture, and aromatic odor.
The increase of extract concentration in gel formula will affect the adhesion
and spreadability. F5 showed the highest anti-inflammatory activity
compared to other groups. This formula was generally identified as having a
good physical appearance, homogeneity, and stability with a pH value of
6.16±0.24, adhesiveness of 51.12±0.15 sec, and a spreadability of
19.54±0.12 cm2. Therefore, Indonesian nutmeg has the potential to be wellacceptable as a candidate for topical anti-inflammatory agents in global
health benefits.

Item Type:	Artikel Dosen
Subjects:	R Medicine > RS Pharmacy and materia medica
Depositing User:	apt lolita umar
Date Deposited:	18 Apr 2023 09:44
Last Modified:	18 Apr 2023 09:44
URI:	http://eprints.uad.ac.id/id/eprint/42968

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