Isolasi mikroalga Aurantiochytrium dari Raja Ampat dan potensinya pada industri bahan baku adjuvant vaksin

Suhendra, Suhendra and Septianingsih, Lia and Ariandi, Tifanny Rizka and Husna, Mar'atul and yuniasih, Dewi and Hutari, Andri and LAKSANA, ZEN ADI (2022) Isolasi mikroalga Aurantiochytrium dari Raja Ampat dan potensinya pada industri bahan baku adjuvant vaksin. [Artikel Dosen]

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Abstract

ECTIVES This paper aims to provide an academic contri�bution to the potential of the microalgae Aurantiochytrium
from Indonesian mangrove forests. This paper presents an
initial overview of research on Aurantiochytrium microalgae
starting from the isolation of microalgae from their habitats,
an overview of production, qualitative analysis techniques of
squalene as well as analysis of economic potential and fun�ctions for vaccine adjuvant raw materials. METHODS A total
of 10 samples of mangrove leaves were taken from the ma�ngrove forests of Raja Ampat,West Papua. Lab-scale biomass
production is presented in this paper. The pure isolate is gro�wn in the nutrients media consisting glucose, yeast extract,
peptone and a mixture of seawater and aquadest. RESULTS
Qualitative analysis of the product produced using Thin Layer
Chromatography (TLC) showed a positive result of the presen�ce of sqalene in the biomass from the cultivation of Auranio�chytrium microalgae. In addition, the potentials of squalene
from the fermented Aurantiochytrium microalgae is discus�sed as a potential disruptive alternative of rawmaterial thatis environmentally friendly and sustainable which can replace conventional squalene production from extracted liver shark oil. Recently, several vaccine adjuvants, including the COVID�19 vaccine, use Aurantiochytriummicroalgae as rawmaterial to replace vaccine adjuvants from deep sea sharks. CONCLU�SIONS In the future, the potential of Aurantiochytrium microalgae products will be increasingly demanded in many heal�th nutrition and cosmetic industries. Given its relevance for
the future of related strategic industries in Indonesia, more
in-depth bioprocess research shall be carried out using indi�genous isolates of Aurantiochytrium microalgae from Indo�nesian mangrove forests.
KEYWORDS Aurantiochytrium; covid-19; microalgae; squale�ne; vaccine adjuvant

Item Type:	Artikel Dosen
Subjects:	Q Science > Q Science (General)
Depositing User:	dr. Dewi Yuniasih
Date Deposited:	30 Oct 2023 09:19
Last Modified:	30 Oct 2023 09:19
URI:	http://eprints.uad.ac.id/id/eprint/51301

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