Systematic Review and Meta-Analysis: Effect of Zinc Levels in COVID-19 Patients on Their Clinical Severity

UNSPECIFIED (2023) Systematic Review and Meta-Analysis: Effect of Zinc Levels in COVID-19 Patients on Their Clinical Severity. [Artikel Dosen]

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Abstract

Zinc has anti-inflammatory, antiviral, and antioxidant effects given as an adjuvant therapy for the treatment of COVID-19. Prolonged zinc deficiency is a risk factor for severe COVID-19. This systematic review and meta-analysis study used 4 databases namely ScienceDirect, Cochrane Library, ProQuest, and PubMed. The keywords used are “Zinc” OR “Severity COVID-19” AND “Zinc Deficiency” OR “Mortality COVID-19” AND “Zinc” OR “Clinical Severity COVID-19” AND “Zinc Deficiency” OR “Clinical Severity COVID-19”. The articles identified are articles that are relevant to the title of research, published internationally, accessed free of charge, published between 2019-2021, and published in accredited journals. Out of 8,330 article titles, 944 were excluded due to double counting in each database. A total of 7,371 articles were excluded and a total of 15 articles were included in the qualitative synthesis. Five studies were included in the meta-analysis. Three studies were analyzed with the results that the average zinclevel of COVID-19 patients was not much different from that of healthy patients with a mean difference of 1.73 (95% CI -39.14-42.60). Two studies were analyzed with low zinc levels in patients with severe COVID-19 associated with the need to enter the intensive care unit with an OR of 3.62 The SARS-CoV-2 virus spreads through droplets that are expelled while coughing or sneezing. The conclusion isthe average zinc level of COVID-19 patients is not different from that of healthy patients, but low zinc levels in patients with severe COVID-19 are associated with the need to enter the intensive care unit

Item Type:	Artikel Dosen
Keyword:	COVID-19Zink levelSeverityDeficiency(consist of 3 to 5 keywords)INTRODUCTION A novel coronavirus known as COVID-19 has the potential to cause ARDS (acute respiratory distress syndrome). The human respiratory tract is attacked by this novel virus, which is currently pandemic all over the world. The majority of COVID-19 infection sufferers experience mild to moderate respiratory disease and recover without the need for special care. People with comorbid conditions such as cardiovascular disease, diabetes mellitus, obesity, hypertension, and advanced age have higher mortality rates1. Angiotensin Converting Enzyme 2 (ACE2) is a receptor on the surface of host cells that SARS-CoV-2 binds to in order to infect humans. The viral S protein mediates the process. SARS-CoV-2 has a higher affinity for the S protein's receptor (human ACE2) than SARS-CoV. Lung cells, particularly
Subjects:	R Medicine > R Medicine (General)
Divisi / Prodi:	Fakultas Kedokteran > S1 - Kedokteran
Depositing User:	dr. Dewi Yuniasih
Date Deposited:	11 Nov 2023 01:15
Last Modified:	11 Nov 2023 01:15
URI:	http://eprints.uad.ac.id/id/eprint/51858

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