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CYP2EI Polymorphism Acetylator Profiles and Drug-Induced Liver Injury Incidence of Indonesian Tuberculosis Patients

Perwitasari, Dyah Aryani and Irham, Lalu Muhammad and Darmawan, Endang and Mulyani, Ully Adhie and Attobhari, Jarir (2016) CYP2EI Polymorphism Acetylator Profiles and Drug-Induced Liver Injury Incidence of Indonesian Tuberculosis Patients. Indian Journal of Tuberculosis, 63 (3). pp. 139-143. ISSN 00195707

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Objective A polymorphism of CYP2E1 may be directly associated with the development of INH hepatotoxicity. We conducted this study to evaluate the association between polymorphisms of CYP2E1, Isoniazid (INH) concentration and the acetylator status of INH in cases of Indonesian tuberculosis patients with drug-induced liver disease (DILI). Methods We conducted our study with a cohort design consisting of 55 Indonesian adult tuberculosis (TB) patients. Acetylating phenotypes were studied in using the metabolic ratio of plasma AcHZ/HZ. DILI was defined using CTCAV version 4.0. The allelic and genotypic frequency distributions of CYP2E1 rs 3813867 were studied using the polymerase chain reaction – amplification refractory mutation system (ARMS) methodology. Results Patients with an INH concentration of more than 7 μg/mL showed a higher risk of developing DILI when compared with patients who showed a therapeutic range of 3–6 μg/mL INH (OR: 1.3, 95% CI: 0.2–8.2). Slow acetylators had a higher incidence of DILI when compared with rapid acetylators (OR: 4.6, 95% CI: 1.3–15.9). Meanwhile, subjects with GC had a higher risk of DILI incidence (OR: 4.3, 95% CI: 0.8–24.4). Conclusion Our study shows that polymorphisms of CYP2E1 and slow acetylator may have role in the DILI incidence. Keywords Hepatotoxicity; Acetylator status; INH; Indonesian; CYP2E1

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User: dyah aryani
Date Deposited: 30 May 2017 04:36
Last Modified: 30 May 2017 04:36

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