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Polymorphism Of PXR Gene Associated With The Increased Risk Of Drug-induced Liver Injury in Indonesian Pulmonary Tuberculosis Patients

Zazuli, Z. and Barliana, M. I and Mulyani, Ully Adhie and Perwitasari, Dyah Aryani and Ng, H. and Abdullah, R. (2015) Polymorphism Of PXR Gene Associated With The Increased Risk Of Drug-induced Liver Injury in Indonesian Pulmonary Tuberculosis Patients. Journal of Clinical Pharmacy and Therapeutics, 40 (6). pp. 1-5. ISSN 1365-2710

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Abstract

What is known and objective : Tuberculosis is still a major infectious disease in Indonesia. Patients are treated mostly using fixed-dose combination treatment in primary public health facilities. The incidence of antituberculosis drug-induced liver injury (AT-DILI) is approximately 10% among Indonesian tuberculosis patients who use standard fixed combination regimens during the intensive phase of treatment. However, information regarding genetic polymorphism associated with the increase risk of drug-induced liver injury is still limited. The aim of this study was to investigate pregnane X receptor (PXR) gene polymorphisms as one of the risk factors of AT-DILI. Methods : In this prospective cohort study, we recruited 106 adult patients diagnosed with pulmonary tuberculosis and treated with category I FDC (fixed-dose combination). The identification of SNP -25385C>T (rs3814055) was conducted by ARMS (amplification refractory mutation system). Hepatotoxicity was defined as ALT and/or AST levels above the normal threshold on the second, fourth and sixth months of monitoring during tuberculosis treatment. Results and discussions : The logistic regression analysis showed that patients with the TT genotype of PXR gene (rs3814055) significantly had a greater risk of AT-DILI (OR 8.89; 95% CI 1.36-57.93, P < 0.05), compared with those of wild-type CC genotype. What is new and conclusions : The result suggests that in Indonesian patients with tuberculosis, the risk of having AT-DILI was associated with TT genotype of the PXR gene.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy (Fakultas Farmasi) > Pharmacy Doc
Depositing User: dyah aryani
Date Deposited: 30 Aug 2017 01:48
Last Modified: 30 Aug 2017 01:48
URI: http://eprints.uad.ac.id/id/eprint/7194

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