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THE EFFECT OF ROSELLA (HIBISCUS SABDARIFFA L) TREATMENT ON IL-10 AND IL-14 SECRETION ON DIMETHYLBENZ (A) ANTHRACENE (DMBA) INDUCED RAT

Nurkhasanah, Nurkhasanah (2015) THE EFFECT OF ROSELLA (HIBISCUS SABDARIFFA L) TREATMENT ON IL-10 AND IL-14 SECRETION ON DIMETHYLBENZ (A) ANTHRACENE (DMBA) INDUCED RAT. International Journal of Pharmacy and Pharmaceutical Sciences, 7 (4). pp. 402-404. ISSN 0975-1491

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Abstract

Objective: The objective of this study was to determine the effect of ethanolic extract rosella calyx pretreatment on increasing secretion of IL-10 and IL-14 on SD rats treated with DMBA. Methods: Rats were treated with a dose of ethanol extract of roselle with 10, 50 and 100 mg / kg BW once daily for 21 days, then treated with DMBA 15mg / rat single dose. One week after DMBA treatment lymphatic organs of mice were taken and the expression of IL-10 and IL-14 were observed by immunohistochemistry using the appropriate antibodies. Further more it was observed using a microscope at 400x magnification. Result: The results showed that the obtained were analyzed using t-test to determine to what the effect of increased secretion of IL-10 and IL-14 between the control and treatment groups. Conclusion: Rosella calyx extract is potential to develop as immunomodulatory agent Keywords: Hibiscus sabdariffa, IL-10, IL14, Immunomodulator.

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User: Dr Nurkhasanah Mahfudh
Date Deposited: 08 Sep 2017 02:29
Last Modified: 08 Sep 2017 02:29
URI: http://eprints.uad.ac.id/id/eprint/7264

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