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THE EFFECT OF Hibiscus sabdarifa L. CALYX ETHANOL EXTRACT ON INCREASING GLUTATHION PEROXIDASE (GPX) ACTIVITY AND DECREASING MALONDIALDEHYDE (MDA) AGAINST 7,12-DIMETHYLBENZ-{A} ANTRASENA (DMBA) INDUCED IN RATS

Wardani, Wahyu Tusi and Nurkhasanah, Nurkhasanah and Bachri, Moch.Saiful (2015) THE EFFECT OF Hibiscus sabdarifa L. CALYX ETHANOL EXTRACT ON INCREASING GLUTATHION PEROXIDASE (GPX) ACTIVITY AND DECREASING MALONDIALDEHYDE (MDA) AGAINST 7,12-DIMETHYLBENZ-{A} ANTRASENA (DMBA) INDUCED IN RATS. Proceeding of “The International Conference on Herbal Medicine Industrialization as Complementary Therapy in Natural Disasters”. pp. 64-75. ISSN 978-979-18458-8-5

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Abstract

Background: The existence of free radicals in the body can lead to cellular damage, tissue, and genetic (mutation). To prevent the adverse effects of free radicals needed antioxidants. body has enzin glutathione peroxidase, is a coenzyme that serves to protect cells from oxygen radical attack. Roselle is one of the plants that can be used as a source of antioxidants. Objective: The objective of this study was to determine the effect of ethanol extract of petals Roselle on the enzyme activity of GPx and activity on levels of malondialdehyde (MDA), in mice DMBA-induced strain SD. Method: Strain male rats of Sprague Dawley (SD) were divided into 5 groups. Group I and II is baseline. Group III-V is ethanol extract of roselle calyx 10, 50, 100 mg / kg. Data were analyzed with Kolmogorof Smirnov test, leven test, ANOVA and LSD tests, Result: The results showed significant differences compared to the activity of GPx DMBA control (p <0.05). An increase in GPx activity in roselle extract, a dose of 10 mg / kg (11.1125 ± 0.62136), a dose of 50 mg / kg (6.31 ± 1.15779), a dose of 100 mg / kg (29.96 ± 1.15536) compared of DMBA (8.7 ± 0.12884) (p <0.05). Antioksigen effects were also seen in roselle extract ability to reduce levels of MDA. Decreased levels of MDA in roselle extract giving a dose of 10 mg / kg (7.86 ± 0.2692), a dose of 50 mg / kg (2.065 ± 0.21947), a dose of 100 mg / kg (1,935 ± 0.39102) compared of DMBA (9.3475 ± 0.22202) (p <0.05). Keywords : Antioxidants, Roselle, glutathione peroxidase (GPx) , malondialdehyde (MDA ), DMBA

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User: Dr Nurkhasanah Mahfudh
Date Deposited: 08 Sep 2017 03:54
Last Modified: 08 Sep 2017 03:54
URI: http://eprints.uad.ac.id/id/eprint/7293

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