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AKTIVITAS ANTIOKSIDAN SEDIAAN NANOPARTIKEL KITOSAN EKSTRAK ETANOL ROSELA (Hibiscus sabdariffa L.) PADA TIKUS HIPERKOLESTEROL TERHADAP AKTIVITAS ENZIM SOD

Zulfa, Elya and Nurkhasanah, Nurkhasanah and Hayu Nurani, Laela (2014) AKTIVITAS ANTIOKSIDAN SEDIAAN NANOPARTIKEL KITOSAN EKSTRAK ETANOL ROSELA (Hibiscus sabdariffa L.) PADA TIKUS HIPERKOLESTEROL TERHADAP AKTIVITAS ENZIM SOD. KARTIKA JURNAL ILMIAH FARMASI, 2 (1). pp. 7-14. ISSN 2354-6565

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Abstract

The aim of this study is to determine the effect of chitosan nanoparticles preparation of ethanol extract of roselle (SNKEER) of the SOD enzyme activity in hypercholesterolemia rats. SNKEER was prepared base on the best optimization results with a ratio of 2: 1: 1/10 (ethanol extract of roselle: chitosan: TPP), further in vivo tests to prepare female white rat strain Sprague Dawley (SD) age of 6-8 weeks with weight number 25 150-250 g were divided into 5 groups: group I was the control group were fed a standard; group II induced hypercholesterolemia; group III, IV, and V induced hypercholesterolemia and SNKEER each with a dose of 25 mg / kg bw / day, 50 mg / kg bw / day, and 100 mg / kg bw / day for 30 days. On day 31, all rats in the grab of blood through the veins to the eye orbital SOD activity were measured by the Ransod Standard method. Data were analyzed using ANOVA followed by Tukey 5% test. The results showed an average measurement of SOD activity in group I, II, III, IV, and V respectively are as follows: 50.96 U / ml, 6.13 U / ml, 16.09 U / ml, 21.07 U / ml, 23.75 U / ml. The results of data analysis showed that variation dose of SNKEER (25,50,100) mg / kg / day can significantly increase the SOD activity when compared with hypercholesterolemia group (P <0.05), while increased activity of SOD was shown significantly in group V, namely hypercholesterolemia group who were given SNKEER 100 mg / kg / day when compared with the treatment group SNKEER with dose of 50 mg / kg / day and 100 mg / kg / day (P <0.05). Keywords : Roselle, hypercholesterolemia, Nanoparticles, Antioxidants, SOD

Item Type: Article
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User: Dr Nurkhasanah Mahfudh
Date Deposited: 12 Oct 2017 05:13
Last Modified: 12 Oct 2017 05:13
URI: http://eprints.uad.ac.id/id/eprint/7650

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