Lotion Preparations of Nutmeg Essential oil (Myristica fragrans Houtt) and Repellent Activity Test against Aedes aegypti Mosquitoes

Azis, Ikhsanudin and Lolita, Lolita Lotion Preparations of Nutmeg Essential oil (Myristica fragrans Houtt) and Repellent Activity Test against Aedes aegypti Mosquitoes. [Artikel Dosen]

Text Lotion Preparations of Nutmeg Essential Oil and Repellent Activity Test Against Aedes aegypti Mosquitoes.pdf Download (346kB)

Abstract

Dengue Hemorrhagic Fever (DHF) is a disease caused by the bite of Aedes aegypti mosquitoes infected with the
Dengue virus. One natural ingredient that can be used as a repellent to prevent mosquito bites is essential oil. Therefore,this research aims to obtain an optimal formulation for nutmeg essential oil lotion, evaluate its influence on lotion properties, assess its skin irritation potential, and determine the repellent activity against female Aedes aegypti mosquitoes.
Nutmeg fruit seed essential oil (Myristica fragrans Houtt) was obtained by distillation. The obtained sample was
qualitatively tested first using GC-MS to determine its components. Lotions were formulated using concentrations of
nutmeg essential oil at 1%, 3%, and 6%. The prepared lotions were tested for their physical properties and repellent
activity using female Aedes aegypti mosquitoes as test animals and irritation test. The test result data were statistically analyzed using one-way ANOVA with a confidence level of 95%. The research results obtained standardization of clear nutmeg seed essential oil, yellow in color, with a distinctive nutmeg scent with a refractive index value of (1.475 ± 0.001) and a relative compound content of alpha-pinene of 19.40%. Increasing the concentration resulted in decreased adhesive force with a value of (p <0.05), increased spreadability (p <0.05), and increased repellent power (p <0.05). All lotions have a pH of 7, are stable for 6 storage cycles, and have an irritation index in the very mild to mild irritation category. The conclusion of this research is that nutmeg seed essential oil lotion formulations with various concentration variations,
namely formula 1 (1%), formula 2 (3%), and formula 3 (6%), have good physical properties, cause very mild to mild skin
irritation, and have the highest repellent activity, which is in formula 3 (6%) at 1098 seconds.

Item Type:	Artikel Dosen
Subjects:	R Medicine > RS Pharmacy and materia medica
Depositing User:	Lolita Lolita
Date Deposited:	11 Feb 2025 07:27
Last Modified:	11 Feb 2025 07:27
URI:	http://eprints.uad.ac.id/id/eprint/80680

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