Nicotine-free vape liquids containing essential oils of peppermint, lavender, and tangerine: safety and efficacy profile

Prasetya, Rahmad Aji and Arifiyana, Djamilah and Syulthoni, Zain Budi (2024) Nicotine-free vape liquids containing essential oils of peppermint, lavender, and tangerine: safety and efficacy profile. Pharmaciana, 14 (3). ISSN ISSN:2088-4559,e-ISSN:2477-0256

Text 4. Aji_299 – 308.pdf Download (371kB)

Abstract

Despite low nicotine levels, cigarettes and vape liquids can cause addiction, which makes quitting
smoking difficult owing to withdrawal syndrome. Hence, we created a nicotine-free liquid vape using
essential oils (EOs) like peppermint (Mentha piperita), lavender (Lavandula latifolia), and tangerine
(Citrus reticulata) to substitute the nicotine in inducing relaxation without addiction. Thus, this study
aimed to examine (1) the safety profile of this nicotine-free liquid vape by observing chemical
characteristics using gas chromatography-mass spectrometry (GC-MS) and (2) its efficacy in reducing
short-term anxiety in healthy volunteers who had previously used nicotine vape. The most complicated
vape liquid formula (F4), containing propylene glycol, vegetable glycerin, with those three EOs, was
injected into GC-MS, and the mass spectra were compared to the Wiley mass spectral library to identify
the compound name. For the efficacy test, subjects who met inclusion criteria and fulfilled informed
consent were randomly assigned to five groups (four groups received test liquids formula (F1-F4) while
one group received placebo). Before and after using the vape liquid, subjects were asked to complete
the State-Trait Anxiety Inventory (STAI) questionnaire to assess its anxiety-reduction effects. The result
showed that nicotine-free vape liquids containing three EOs did not show any foreign substances that
had never been encountered before, which means our product is safer than nicotine-containing vape
liquids. This safety was also supported by all study subjects who did not report any adverse effects. The
efficacy test showed that subjects who used vape liquids with essential oils (F1-F4) experienced a
significant decrease in heart rate and systolic blood pressure. At the same time, 50% had a lower posttest
STAI score, indicating a decrease in anxiety, although it was not statistically significant.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	19 Apr 2025 07:44
Last Modified:	19 Apr 2025 07:44
URI:	http://eprints.uad.ac.id/id/eprint/83050

Actions (login required)

View Item