Use of bitter melon seed oil (Momordica charantia) to improve the photoprotective effect of sunscreen formulations

Winarti, Lina and Refayani, Ema Prastiwi (2024) Use of bitter melon seed oil (Momordica charantia) to improve the photoprotective effect of sunscreen formulations. Pharmaciana, 14 (3). ISSN ISSN:2088-4559,e-ISSN:2477-0256

Text 8. Winarti_346 – 355.pdf Download (417kB)

Abstract

Bitter melon seed oil (BMSO) was identified as having the potential as an anti-UV radiation agent due to alpha-oleo stearic acid, flavonoids, tannins, polyphenols, and phytosterols, which have the potential as antioxidants. Antioxidants are the main protection for the skin from the dangers of solar radiation, making BMSO a good quality if developed in sunscreen cream. This research aims to determine the effect of adding variations in the concentration of BMSO on the physical characteristics and in vitro photoprotective effectiveness of oxybenzone and octyl methoxycinnamate cream. Sunscreen creams are made with each BMSO concentration of 0%, 6%, 8%, 10%, and 12%. The result shows that the greater the concentration of BMSO added, the lower the viscosity and pH values, the %TP (percentage of transmission pigmentation) and %TE (percentage of transmission erythema), while the spreadability and SPF (sun protection factor) values of the cream increase. The best formula contains the highest concentration of BMSO (12%). The characteristics of the best formula are a slightly yellowish, soft cream and a slight smell typical of bitter melon. The spreadability value of the best formula cream is 6.6 ± 0.1 cm, pH is 6.57 ± 0.01, and viscosity is 88.3 ± 4.1 dPa.s, SPF value is 24.27 ± 0.28, %TE is 0.931 ±0.084, and %TP is 0.981±0.0001. These results show that BMSO has the potential to be an active ingredient in sunscreen to reduce the negative effects of using synthetic sunscreen, such as allergenic and irritant.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	21 Apr 2025 01:23
Last Modified:	21 Apr 2025 01:23
URI:	http://eprints.uad.ac.id/id/eprint/83054

Actions (login required)

View Item