Utilization of purple sweet potato synbiotic drink as a source of lactic acid bacteria exopolysaccharides for immunomodulation

Almira, Rehan and Winarsih, Sri and Manshur, Hanif Alamudin (2025) Utilization of purple sweet potato synbiotic drink as a source of lactic acid bacteria exopolysaccharides for immunomodulation. Pharmaciana, 15 (1). ISSN ISSN:2088-4559,e-ISSN:2477-0256

Text 3.Manshur_19-28.pdf Download (399kB)

Abstract

Immunomodulators, such as exopolysaccharides (EPS), can be found in products processed through
lactic acid bacteria (LAB) fermentation. Purple sweet potatoes have the potential to be used as
ingredients for making synbiotic drinks because of the high content of oligosaccharides. This study
aimed to determine the effectiveness of purple sweet potato synbiotic drinks in improving the immune
system in vivo. The experiment was conducted on male mice (Balb-C, 12 weeks old, 25±5 g BW) which
were given purple sweet potato synbiotic drink for 14 days with doses of A1, A2, and A3 (50, 100, 150
mg/kg BW) given once a day. On the 14th day, the mice were induced with S. aureus bacteria given
intraperitoneally (1 mL, 108 cfu/mL). The immunomodulation-related parameters measured were
phagocytic activity, the number of lymphocyte cells, and the relative spleen weight of mice. The results
showed that the synbiotic drink of purple sweet potato (A1, A2, and A3) can increase phagocytic activity
and lymphocyte cell count and have a significant effect on relative spleen weight (p<0.05). The higher
the dose of synbiotic drink, the higher the phagocytic activity and the number of lymphocyte cells, and
the smaller the relative spleen weight of the mice.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	21 Apr 2025 01:13
Last Modified:	21 Apr 2025 01:13
URI:	http://eprints.uad.ac.id/id/eprint/83091

Actions (login required)

View Item