Formulation of a sheet mask essence incorporating Betel leaf (Piper betle L.) ethanol extract and its antibacterial efficacy against Propionibacterium acnes

Wulandari, Annisa Dyah and Sunarto, Sunarto and Kurniawan, Dhadhang Wahyu Formulation of a sheet mask essence incorporating Betel leaf (Piper betle L.) ethanol extract and its antibacterial efficacy against Propionibacterium acnes. Pharmaciana, 15 (1). ISSN ISSN:2088-4559,e-ISSN:2477-0256

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Abstract

Betel leaf (Piper betle L.) encompasses a multitude of bioactive constituents, including tannins,
saponins, flavonoids, alkaloids, and terpenoids, which possess significant antibacterial properties. An
ethanol extract derived from betel leaf was meticulously formulated and assessed for its potential as an
antibacterial agent specifically targeting Propionibacterium acnes, a bacterium associated with the
etiology of acne. This investigation was undertaken with the aim of mitigating the antibiotic resistance
commonly observed with traditional acne therapies. The ethanol extract of betel leaf was incorporated
into a sheet mask essence, resulting in the development of four distinct formulations (F0, F1, F2, and
F3), which were subsequently subjected to comprehensive evaluations of their physical quality and
stability. The formulation exhibiting optimal physical characteristics and stability was further
scrutinized for its antibacterial efficacy against Propionibacterium acnes. The antibacterial performance
of the selected formulation was benchmarked against a positive control comprising a sheet mask infused
with clindamycin gel, as well as another containing tea tree oil. Empirical results identified Formula 2,
containing 1.5% ethanol extract of betel leaf, as the most efficacious formulation. Formula 2
demonstrated pronounced antibacterial activity against Propionibacterium acnes, with an inhibitory
zone measuring 24.67 mm. Although this inhibitory zone was slightly less extensive than that produced
by the clindamycin gel sheet mask (32.00 mm), it was comparable to the tea tree oil sheet mask, which
exhibited an inhibitory zone of 23.00 mm. In conclusion, the selected sheet mask formulation (Formula
2) exhibits significant antibacterial activity against Propionibacterium acnes, surpassing the efficacy of
commercially available tea tree oil sheet masks, thereby presenting a promising alternative for acne
management with a diminished risk of promoting antibiotic resistance.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	21 Apr 2025 01:16
Last Modified:	21 Apr 2025 01:16
URI:	http://eprints.uad.ac.id/id/eprint/83099

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