Na-CMC and glycerine optimization in Binahong leaf extract (Anredera cordifolia) liposome gel and its burn wound healing activity

Immanuel, Handika and Branitasandini, Regina Epiphania Adhika and Arpan, Verdynant Augusto and Pebrianty, Sahara and Kerenhapukh, Miracle and Wardhani, Kresentia Ayu Kusuma and Yuliani, Sri Hartati Na-CMC and glycerine optimization in Binahong leaf extract (Anredera cordifolia) liposome gel and its burn wound healing activity. Pharmaciana, 15 (1). ISSN ISSN:2088-4559,e-ISSN:2477-0256

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Abstract

Burns represent a critical global health issue, contributing to considerable morbidity and mortality
rates, particularly within the Southeast Asian region. The administration of appropriate burn therapy is
essential to prevent infections and promote effective wound healing. The binahong leaf (Anredera
cordifolia) represents a highly promising natural substance for burn therapy, attributed to its ursolic acid
content, which is acknowledged for its wound healing properties. However, the limitation caused by its
limited solubility and bioavailibility requires the use of nanoparticle technology, such as liposomes, to
enhance its efficacy. The aim of this research was to determine an optimal formulation of gel containing
liposome-encapsulated binahong leaf extract, with the goal of promoting burn wound healing and
examining its in vivo wound healing activity. Histological analysis was employed to provide additional
insights into the activity of the gel. The formulation was assessed through a factorial design, exploring
various amounts of Na-CMC utilized as a gelling agent alongside glycerine employed as a humectant.
The results were subsequently analyzed utilizing Design Expert v13 software. The gel’s viscosity,
spreadability, and uniformity were assessed. Na-CMC increased viscosity while reducing spreadability,
whereas glycerine had the opposite effect. The optimal formulation contained 2.78–4 g Na-CMC and 5–
10 g glycerine. Statistical validation confirmed the model's accuracy. In vivo studies demonstrated that
liposomal binahong gel significantly accelerated burn wound healing compared to controls. The results
suggest that 10% binahong liposomal gel is a promising alternative for burn treatment.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisi / Prodi:	Faculty of Pharmacy (Fakultas Farmasi) > S1-Pharmacy (S1-Farmasi)
Depositing User:	jurnal pharmaciana
Date Deposited:	21 Apr 2025 01:16
Last Modified:	21 Apr 2025 01:16
URI:	http://eprints.uad.ac.id/id/eprint/83101

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