The influence of black cumin seed oil therapy with dosage of 1.5 mL/day and 3 mL/day to interleukin-21 (IL-21) expression of the patients with metabolic syndrome risk

Fajar, D R and Akrom, Akrom and Darmawan, E (2017) The influence of black cumin seed oil therapy with dosage of 1.5 mL/day and 3 mL/day to interleukin-21 (IL-21) expression of the patients with metabolic syndrome risk. IOP Conference Series: Materials Science and Engineering, 259. 012012. ISSN 1757-8981

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Abstract

Metabolic syndrome (MS) is a metabolic disorder caused by obesity and insulin
resistance. In the state of obesity and insulin resistance occurs increased fat metabolism that
causes production reactive oxygen species (ROS) and oxidative stress that makes dysregulation
of adipose tissue that decreases antioxidant enzymes and immune system disorders. In diabetes
mellitus there is pancreatic β cell damage caused by pro-inflammatory cytokines i.e
interleukin-21 (IL-21). Black cumin seed oil (BCSO) contains antioxidants and
immunomodulators but has not seen how it affects to IL-21. This study used cross over design
to determine the effect of BCSO with dose of 1.5 mL/day and 3 mL/day dose of IL-21 in MS
patients. The total subjects 66 of MS patients were divided into 2 groups. Group I was
administered 1.5 mL/day and 3 mL/day of BCSO in dosage for 20 days and continued with
washing out (BCSO discontinued) for 7 days. On the day 28, group I administrated 3 mL/day
of BCSO and group II were given 1.5 mL/day of BCSO during 20 days. Statistical analysis
showed that mean value expression of IL-21 were given by BCSO at dose 1.5 mL/day was
5.06±5.48 and BCSO at dose 3 mL/day 4.66±3.63 (p<0.05). The result showed that IL-21
expression in patient at risk of MS who received BCSO dose 3 mL/day were lower than those
received adose of 1.5 mL/day for 20 days.

Item Type:	Artikel Umum
Subjects:	R Medicine > RS Pharmacy and materia medica
Depositing User:	Akrom Akrom
Date Deposited:	22 Jan 2018 07:50
Last Modified:	22 Jan 2018 07:50
URI:	http://eprints.uad.ac.id/id/eprint/8604

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