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Formulasi Kapsul Ekstrak Etanol Akar Pasak Bumi (Eurycoma longifolia Jack.,)dan Pengaruhnya terhadap Vital Sign Manusia Sehat

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Nurani, Laela Hayu and Kumalasari, Eka and Rohman, Abdul and Widyarini, Sitarina (2017) Formulasi Kapsul Ekstrak Etanol Akar Pasak Bumi (Eurycoma longifolia Jack.,)dan Pengaruhnya terhadap Vital Sign Manusia Sehat. Fakultas Farmasi, Universitas Gadjah Mada.

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Abstract

Pasak bumi (Eurycoma longifolia) has the potential to be developed as antihypertensive, antipyretic, aphrodisiacs and health supplements. The use of E. longifolia as a traditional medicine needs to be pursued in the form of more effective and appropriate formulation. The capsule preparations are easy to make and can cover the bitter taste of E. longifolia. Clinical trials in this study use design pre-post treatment in healthy humans. Subjects used were male - healthy men and healthy women who met inclusion criteria and were subjected with formulated capsule for 14 days. The study resulted capsule formula comprising of the ethanolic extract of E. longifolia 300 mg, vivapur 101 300 mg, 58 mg maydis starch, aerosil 3%, talc 2%, and Mg stearate 1%. The results showed that the capsule of E. longifolia did not affect the value of heart rate, respiration rate, body temperature and weight (P > 0.05), based on paired t-test, but they causes a decrease in blood pressure of healthy human. The ethanol extract of E. longifolia caused vasodilation of blood vessels that can be used in antihypertensive therapy. Keywords: Eurycoma longifolia, capsules, vital sign.

Item Type: Other
Subjects: R Medicine > RM Therapeutics. Pharmacology
R Medicine > RS Pharmacy and materia medica
Divisions: Faculty of Pharmacy (Fakultas Farmasi) > S2-Master of Pharmacy (S2-Farmasi)
Depositing User: Unnamed user with email laelafarmasi@yahoo.com
Date Deposited: 07 Mar 2018 07:03
Last Modified: 07 Mar 2018 07:03
URI: http://eprints.uad.ac.id/id/eprint/8945

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